中国肺癌杂志
中國肺癌雜誌
중국폐암잡지
CHINESE JOURNAL OF LUNG CANCER
2009年
7期
770-774
,共5页
田墨涵%于丽娟%段钰%王欣
田墨涵%于麗娟%段鈺%王訢
전묵함%우려연%단옥%왕흔
肺肿瘤%18氟-脱氧葡萄糖%体层摄影术%发射型计算机%免疫组织化学%葡萄糖转运蛋白-1
肺腫瘤%18氟-脫氧葡萄糖%體層攝影術%髮射型計算機%免疫組織化學%葡萄糖轉運蛋白-1
폐종류%18불-탈양포도당%체층섭영술%발사형계산궤%면역조직화학%포도당전운단백-1
Lung neoplasms%Tomography%PET computed%18F-2-fluoro-deoxT-D-glucose%lmmunohistochemicaltechnique%Glutl protein
背景与目的 Glutl是介导葡萄糖转运的主要载体,同病灶对FDG的摄取程度呈正相关,但同肺癌CT征象的关系尚不十分清楚,本研究通过FDG PET/CT显像,筛选可以反映非小细胞肺癌葡萄糖代谢水平的CT征象和临床病理指标.方法 对33例肺癌(鳞癌11,腺癌22例)术前行PET/CT检查,收集病理类型、分化程度、有无淋巴结转移结果 ;评价CT征象(包括直径、深分叶征、细短毛刺征、棘突征、空泡征、血管集束征、胸膜凹陷征);视觉分析和SUVmax分析病灶对FDG的摄取程度;免疫组织化学SP法检测肿瘤组织Glutl的表达.结果 Glutl的阳性表达率为66.67%;鳞癌Glutl的阳性表达率和SUVmax明显高于腺癌(P双边=0.037,P单边=0.045);≥2cm组对FDG的摄取程度(视觉分析和SUVmax)和Glutl的阳性表达率明显高于<2cm组(P双边=0.002,P双边=0.001,P单边=0.049);视觉分析示有细短毛刺征组肺癌对FDG的摄取程度显著高于无细短毛刺征组(p双边=0.006).结论 肺癌的大小和细短毛刺征可反映肿瘤葡萄糖代谢水平,肺鳞癌的葡萄糖的代谢水平高于肺腺癌.
揹景與目的 Glutl是介導葡萄糖轉運的主要載體,同病竈對FDG的攝取程度呈正相關,但同肺癌CT徵象的關繫尚不十分清楚,本研究通過FDG PET/CT顯像,篩選可以反映非小細胞肺癌葡萄糖代謝水平的CT徵象和臨床病理指標.方法 對33例肺癌(鱗癌11,腺癌22例)術前行PET/CT檢查,收集病理類型、分化程度、有無淋巴結轉移結果 ;評價CT徵象(包括直徑、深分葉徵、細短毛刺徵、棘突徵、空泡徵、血管集束徵、胸膜凹陷徵);視覺分析和SUVmax分析病竈對FDG的攝取程度;免疫組織化學SP法檢測腫瘤組織Glutl的錶達.結果 Glutl的暘性錶達率為66.67%;鱗癌Glutl的暘性錶達率和SUVmax明顯高于腺癌(P雙邊=0.037,P單邊=0.045);≥2cm組對FDG的攝取程度(視覺分析和SUVmax)和Glutl的暘性錶達率明顯高于<2cm組(P雙邊=0.002,P雙邊=0.001,P單邊=0.049);視覺分析示有細短毛刺徵組肺癌對FDG的攝取程度顯著高于無細短毛刺徵組(p雙邊=0.006).結論 肺癌的大小和細短毛刺徵可反映腫瘤葡萄糖代謝水平,肺鱗癌的葡萄糖的代謝水平高于肺腺癌.
배경여목적 Glutl시개도포도당전운적주요재체,동병조대FDG적섭취정도정정상관,단동폐암CT정상적관계상불십분청초,본연구통과FDG PET/CT현상,사선가이반영비소세포폐암포도당대사수평적CT정상화림상병리지표.방법 대33례폐암(린암11,선암22례)술전행PET/CT검사,수집병리류형、분화정도、유무림파결전이결과 ;평개CT정상(포괄직경、심분협정、세단모자정、극돌정、공포정、혈관집속정、흉막요함정);시각분석화SUVmax분석병조대FDG적섭취정도;면역조직화학SP법검측종류조직Glutl적표체.결과 Glutl적양성표체솔위66.67%;린암Glutl적양성표체솔화SUVmax명현고우선암(P쌍변=0.037,P단변=0.045);≥2cm조대FDG적섭취정도(시각분석화SUVmax)화Glutl적양성표체솔명현고우<2cm조(P쌍변=0.002,P쌍변=0.001,P단변=0.049);시각분석시유세단모자정조폐암대FDG적섭취정도현저고우무세단모자정조(p쌍변=0.006).결론 폐암적대소화세단모자정가반영종류포도당대사수평,폐린암적포도당적대사수평고우폐선암.
Background and objective Glutl is the main carrier which intervenes the glucose uptake of cell, and the expression of Glutl was positively correlated to the uptake of FDG. The aim of this study is to select the CT characteristics and clinicopathological parameters which can refect the levels of glucose metabolism of human non-small lung cancer (NSLC). Methods Thirty-three cases of the NSLC (squamous carcinoma 11 cases and adenocarcinoma 22 cases) have undergone the scanning of FDG PET/CT before operation. The tumor pathological classification, degree of differentiation and lymph node me-tastasis were collected. The CT characteristics which included the diameter, deep lobulation, thin and short spiculation, spinous protuberance, cavity sign, vessel convergence sign and pleural retraction sign were described. Tracer uptake of suspected lesious was assessed by visual assessment and quantitatively by the maximum standardized uptake values (SUVmax).The expression of Ghitl which were examined by means of SP immunohistochemical technique was also analyzed. Results The positive rate of Glut1 was 66.67% (squamous carcinoma was 90.91% and adenocarcinoma was 54.55%). The positive rate of Glut1 and SUVmax of squamous carcinoma were significant higher than adenocarcinoma (Pbilateral=0.037, Punilateral=0.045). Through visual assess-ment and SUVmax, the uptake and the positive rate of Glutl which size ≥2 cm were higher than the size <2 cm (Pbilateral=0.002,Pbilateral=0.001, Punilateral=0.049). The uptake intense of FDG was related to the thin and short spiculation through visual assessment(Pbilateral=0.006). Conclusion The study suggested that the levels of glucose metabolism of squamous carcinoma higher than ad-enocarcinoma, the diameter upper than 2 cm and the thin and short speculation were higher.
