CAJ | 학술논문

肾素-血管紧张素系统(renin-angiotensin system,RAS)具有调节血压和水钠平衡的生理作用.近年来,研究发现RAS在多种肺部疾病中发挥作用,例如肺动脉高压、肺纤维化、肺血栓栓塞症和急性呼吸窘迫综合征.最近发现RAS中的血管紧张素转化酶2(angiotensin-converting enzyme 2,ACE2)是SARS冠状病毒的受体,且病毒感染后ACE2下调可能是SARS患者肺损伤显著加重的原因.这些发现提示RAS与肺部疾病存在重要关系.
신소-혈관긴장소계통(renin-angiotensin system,RAS)구유조절혈압화수납평형적생리작용.근년래,연구발현RAS재다충폐부질병중발휘작용,례여폐동맥고압、폐섬유화、폐혈전전새증화급성호흡군박종합정.최근발현RAS중적혈관긴장소전화매2(angiotensin-converting enzyme 2,ACE2)시SARS관상병독적수체,차병독감염후ACE2하조가능시SARS환자폐손상현저가중적원인.저사발현제시RAS여폐부질병존재중요관계.
Renin-angiotensin system(RAS) maintains blood pressure homeostasis,as well as fluid and salt balance. In recent years,researches showed that RAS implicates in the pathogenesis of several pulmonary diseases, such as pulmonary hypertension, pulmonary fibrosis, pulmonary thromboembolism and acute respiratory distress syndrome. In particular, recent studies revealed that angiotensin-converting enzyme 2 (ACE2) is an essential receptor of SARS-CoV,and it will markedly downregulate in lung during SARS-CoV infections. The downregulation of ACE2 might be an important reason of severe lung injury in SARS patients. These discoveries indicate that there are important relations between RAS and pulmonary diseases.