CAJ | 학술논문

代谢组学是继基因组学、转录组学和蛋白质组学之后的一门新兴学科,目前已成功地运用到多学科领域,在疾病诊断、药物评价以及临床研究中发挥了重要作用.代谢组学的研究内容是生物体系中小分子代谢中间体和终产物,核磁共振和色谱-质谱的分析技术是代谢组学研究的两种主要技术手段.现综述近年来代谢组学分析技术及数据处理技术的研究进展,重点讨论代谢组学在糖尿病研究领域的应用,并对当前代谢组学研究中存在的问题及发展趋势进行探讨.
대사조학시계기인조학、전록조학화단백질조학지후적일문신흥학과,목전이성공지운용도다학과영역,재질병진단、약물평개이급림상연구중발휘료중요작용.대사조학적연구내용시생물체계중소분자대사중간체화종산물,핵자공진화색보-질보적분석기술시대사조학연구적량충주요기술수단.현종술근년래대사조학분석기술급수거처리기술적연구진전,중점토론대사조학재당뇨병연구영역적응용,병대당전대사조학연구중존재적문제급발전추세진행탐토.
Metabonomics is becoming a new branch of science after genomics, transcriptomics and proteomics, which has been successfully applied in lots of fields such as disease diagnosis, pharmaceutical re-search and clinical therapy. The main research objects of metabonomics are the metabolites with low molecu-lar weight in a given bio-system. At present,nuclear magnetic resonance and chromatography mass-spectrome-try based methodologies are the main two types of technologies in metabonomics. In this paper, the recent de-velopment of the analytical and data processing techniques used in metabonomics are reviewed. And the ap-plications of metabonomics in the field of diabetes mellitus are mainly discussed. The problems and the future perspective of metabonomics research were also discussed.