CAJ | 학술논문

目的探讨~(18)氟-脱氧葡萄糖(~(18)F-FDG)正电子发射断层显像(PET)在儿童恶性淋巴瘤分期、疗效评估及随诊中的意义.方法回顾性分析88例儿童恶性淋巴瘤初诊时、化疗中期及停药后随诊过程中~(18)F-FDG-PET扫描结果,并与同期的CT扫描相比较.结果 67例初诊儿童淋巴瘤患者,化疗前共评估了1072个解剖部位,PET和CT均提示瘤灶阳性及阴性部位分别为11.10%和77.52%,PET阳性CT阴性的部位占6.8l%,而PET阴性CT阳性的占4.57%,PET在化疗前受累部位的诊断方面优于CT扫描.对26例随诊患者,在治疗中期、停药时及停药后进行了35次PET检查,32例次患儿瘤灶为阴性,PET扫描瘤灶真阴性为28例次(真阴性率为87.50%),CT为16例次(真阴性率为57.14%),在假阳性方面,CT比较高,为16例次(假阳性率为50.00%),而PET仅为4例次(假阳性率为12.50%), 临床吻合度PET大于CT.结论 PET对于儿童恶性淋巴瘤的临床分期、鉴别残余病灶的性质以避免不必要的过度治疗或二次活检,以及发现肿瘤的早期复发具有一定的意义.
목적 탐토~(18)불-탈양포도당(~(18)F-FDG)정전자발사단층현상(PET)재인동악성림파류분기、료효평고급수진중적의의.방법 회고성분석88례인동악성림파류초진시、화료중기급정약후수진과정중~(18)F-FDG-PET소묘결과,병여동기적CT소묘상비교.결과 67례초진인동림파류환자,화료전공평고료1072개해부부위,PET화CT균제시류조양성급음성부위분별위11.10%화77.52%,PET양성CT음성적부위점6.8l%,이PET음성CT양성적점4.57%,PET재화료전수루부위적진단방면우우CT소묘.대26례수진환자,재치료중기、정약시급정약후진행료35차PET검사,32례차환인류조위 음성,PET소묘류조진음성위28례차(진음성솔위87.50%),CT위16례차(진음성솔위57.14%),재 가양성방면,CT비교고,위16례차(가양성솔위50.00%),이PET부위4례차(가양성솔위12.50%), 림상문합도PET대우CT.결론 PET대우인동악성림파류적림상분기、감별잔여병조적성질이피면불 필요적과도치료혹이차활검,이급발현종류적조기복발구유일정적의의.
Objective To investigate the value of Fluorine-18 fluorodeoxyglucose positron emission tomography (~(18)F-FDG-PET)in staging and detecting residual disease during follow-up of non-Hodgkin's lymphoma in children. Methods The results of~(18)F-FDG-PET of 88 podiatric NHL before and after chemotherapy was analyzed respectively.The results were compared with CT scans simultaneously.Results 67 cases were performed for initial staging.Of the 1072 anatomy regions were analyzed by PET and CT with concordalice of 88.62%regions(positive in 11.10%and negative in 77.52%1.Disconcordance were found in 11.38%regions(PET positive but CT negative in 6.8 1%,PET negative but CT positive in 4.57%).PET was significantly better than CT scan in the staging of podiatric NHL.35 scans were performed in the follow-up.The true residual disease positive rate of PET and CT were 87.50%and 57.14% respectively.The false positive rate of PET and CT were 12.50%and 50.00%respectively.Conclusion ~ (18)SF-FDG-PET imaging is of great value for the staging of the pediatric patients with NHL It's a useful technique to identify the residual disease,avoid unnecessary treatment and biopsy and Can predict eady relapse.