中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
31期
18-20
,共3页
丹参%川芎嗪%糖尿病,2型%糖尿病神经病变%甲钴胺
丹參%川芎嗪%糖尿病,2型%糖尿病神經病變%甲鈷胺
단삼%천궁진%당뇨병,2형%당뇨병신경병변%갑고알
Salvia miltiorrhiza%Tetramethylpyrazine%Diabetes mellitus%type 2%Diabetic neuropathies%Methylcobalamin
目的 观察丹参川芎嗪注射液联合甲钴胺治疗2型糖尿病周围神经病变的临床疗效.方法 112例2型糖尿病周围神经病变患者按随机数字表法分为两组,对照组56例采用甲钴胺治疗,观察组56例在对照组基础上加用丹参川芎嗪注射液治疗,比较两组的临床疗效及腓总神经、胫神经运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)的变化.结果 观察组总有效率为87.5％(49/56),明显高于对照组的57.1％(32/56),差异有统计学意义(P＜0.05).观察组治疗后腓总神经、胫神经MNCV和SNCV分别为(47.89±6.93)、(49.12±5.54) m/s和(43.69±4.97)、(42.35±5.14) m/s,与治疗前比较明显升高(P＜0.05),而对照组分别为(41.15±4.36)、( 39.89±3.67) m/s和(37.57±3.08)、(36.56±2.81) m/s,与治疗前比较差异无统计学意义(P＞0.05).并且,观察组治疗后腓总神经、胫神经MNCV和SNCV均明显高于对照组,差异有统计学意义(P＜0.05).结论 丹参川芎嗪注射液联合甲钴胺治疗2型糖尿病周围神经病变,能够明显提高临床疗效,改善患者的神经功能状态,值得临床推广应用.
目的 觀察丹參川芎嗪註射液聯閤甲鈷胺治療2型糖尿病週圍神經病變的臨床療效.方法 112例2型糖尿病週圍神經病變患者按隨機數字錶法分為兩組,對照組56例採用甲鈷胺治療,觀察組56例在對照組基礎上加用丹參川芎嗪註射液治療,比較兩組的臨床療效及腓總神經、脛神經運動神經傳導速度(MNCV)和感覺神經傳導速度(SNCV)的變化.結果 觀察組總有效率為87.5％(49/56),明顯高于對照組的57.1％(32/56),差異有統計學意義(P＜0.05).觀察組治療後腓總神經、脛神經MNCV和SNCV分彆為(47.89±6.93)、(49.12±5.54) m/s和(43.69±4.97)、(42.35±5.14) m/s,與治療前比較明顯升高(P＜0.05),而對照組分彆為(41.15±4.36)、( 39.89±3.67) m/s和(37.57±3.08)、(36.56±2.81) m/s,與治療前比較差異無統計學意義(P＞0.05).併且,觀察組治療後腓總神經、脛神經MNCV和SNCV均明顯高于對照組,差異有統計學意義(P＜0.05).結論 丹參川芎嗪註射液聯閤甲鈷胺治療2型糖尿病週圍神經病變,能夠明顯提高臨床療效,改善患者的神經功能狀態,值得臨床推廣應用.
목적 관찰단삼천궁진주사액연합갑고알치료2형당뇨병주위신경병변적림상료효.방법 112례2형당뇨병주위신경병변환자안수궤수자표법분위량조,대조조56례채용갑고알치료,관찰조56례재대조조기출상가용단삼천궁진주사액치료,비교량조적림상료효급비총신경、경신경운동신경전도속도(MNCV)화감각신경전도속도(SNCV)적변화.결과 관찰조총유효솔위87.5％(49/56),명현고우대조조적57.1％(32/56),차이유통계학의의(P＜0.05).관찰조치료후비총신경、경신경MNCV화SNCV분별위(47.89±6.93)、(49.12±5.54) m/s화(43.69±4.97)、(42.35±5.14) m/s,여치료전비교명현승고(P＜0.05),이대조조분별위(41.15±4.36)、( 39.89±3.67) m/s화(37.57±3.08)、(36.56±2.81) m/s,여치료전비교차이무통계학의의(P＞0.05).병차,관찰조치료후비총신경、경신경MNCV화SNCV균명현고우대조조,차이유통계학의의(P＜0.05).결론 단삼천궁진주사액연합갑고알치료2형당뇨병주위신경병변,능구명현제고림상료효,개선환자적신경공능상태,치득림상추엄응용.
Objective To observe the effect of salvia lignstrazine combined with methylcobalamin in treatment of type 2 diabetic peripheral neuropathy.Methods From May 2010 to May 2011,112 cases of type 2 diabetic peripheral neuropathy patients were classified into two groups by random digits table,control group of 56 cases were treated with methylcobalamin and observation group of 56 cases were treated with salvia lignstrazine combined with methylcobalamin.The clinical effects,motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) of common peroneal nerve and tibial nerve between two groups were compared.Results The total effective rate in observation group was 87.5％(49/56),which was significantly higher than that in control group [ 57.1％( 32/56 ) ] (P ＜ 0.05 ).After treatment,the levels of MNCV and SNCV of common peroneal nerve and tibial nerve were (47.89 ± 6.93 ),(49.12 ± 5.54) m/s and (43.69 ± 4.97 ),(42.35 ± 5.14) m/s in observation group,which were significantly increased compared with those before treatment,while the levels of MNCV and SNCV of common peroneal nerve and tibial nerve were (41.15 ± 4.36),(39.89 ± 3.67 ) m/s and (37.57 ± 3.08),(36.56 ± 2.81 ) m/s in control group,which had no significant difference compared with those before treatment (P ＞ 0.05 ).Moreover,the levels of MNCV and SNCV of common peroneal nerve and tibial nerve in observation group were significantly higher than those in control group (P＜ 0.05).Conclusion Salvia ligustrazine combined with methylcobalamin in treatment of type 2 diabetic peripheral neuropathy can enhance the clinical effects,and improve neurological status,and can be applied in clinic.
