中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
4期
443-444
,共2页
王军%张宝良%袁庆鑫%米立国
王軍%張寶良%袁慶鑫%米立國
왕군%장보량%원경흠%미입국
复合消蚀法%脱细胞真皮基质%筋膜组织%聚丙烯补片
複閤消蝕法%脫細胞真皮基質%觔膜組織%聚丙烯補片
복합소식법%탈세포진피기질%근막조직%취병희보편
Complex maceration%Acelluar dermal matrix%Fascial%Marlex mesh
目的 探讨复合消蚀法制备的脱细胞真皮基质(ADM)和聚丙烯补片(Marlex网)修补大鼠腹壁疝的应用价值.方法 用全厚猪皮制备ADM,选用SD雄性大鼠45只,完全随机分为腹壁疝组7只、Marlex网组10只和ADM组28只,观察3组术后1周时有无腹壁疝的发生,术后第5周Marlex网组和ADM组随机选取6只用于抗张力试验.结果 术后1周时,ADM组与Marlex网组腹壁疝发生率均明显低于腹壁疝组(分别为0.04%、0.00%、100.00%,P＜0.01),但ADM组与Marlex网组差异无统计学意义(P＞0.05).将单独ADM片与Marlex网行抗张力试验,Marlex网的抗张力远高于ADM[(417±44)N比(111±27)N,P＜0.01].但植入体内5周后,ADM-筋膜组织的抗张力高于Marlex-筋膜组织[(103±27)N比(71±19)N,P＜0.05].结论 复合消蚀法制备的ADM可能比聚丙烯补片更适合作为疝修补材料.
目的 探討複閤消蝕法製備的脫細胞真皮基質(ADM)和聚丙烯補片(Marlex網)脩補大鼠腹壁疝的應用價值.方法 用全厚豬皮製備ADM,選用SD雄性大鼠45隻,完全隨機分為腹壁疝組7隻、Marlex網組10隻和ADM組28隻,觀察3組術後1週時有無腹壁疝的髮生,術後第5週Marlex網組和ADM組隨機選取6隻用于抗張力試驗.結果 術後1週時,ADM組與Marlex網組腹壁疝髮生率均明顯低于腹壁疝組(分彆為0.04%、0.00%、100.00%,P＜0.01),但ADM組與Marlex網組差異無統計學意義(P＞0.05).將單獨ADM片與Marlex網行抗張力試驗,Marlex網的抗張力遠高于ADM[(417±44)N比(111±27)N,P＜0.01].但植入體內5週後,ADM-觔膜組織的抗張力高于Marlex-觔膜組織[(103±27)N比(71±19)N,P＜0.05].結論 複閤消蝕法製備的ADM可能比聚丙烯補片更適閤作為疝脩補材料.
목적 탐토복합소식법제비적탈세포진피기질(ADM)화취병희보편(Marlex망)수보대서복벽산적응용개치.방법 용전후저피제비ADM,선용SD웅성대서45지,완전수궤분위복벽산조7지、Marlex망조10지화ADM조28지,관찰3조술후1주시유무복벽산적발생,술후제5주Marlex망조화ADM조수궤선취6지용우항장력시험.결과 술후1주시,ADM조여Marlex망조복벽산발생솔균명현저우복벽산조(분별위0.04%、0.00%、100.00%,P＜0.01),단ADM조여Marlex망조차이무통계학의의(P＞0.05).장단독ADM편여Marlex망행항장력시험,Marlex망적항장력원고우ADM[(417±44)N비(111±27)N,P＜0.01].단식입체내5주후,ADM-근막조직적항장력고우Marlex-근막조직[(103±27)N비(71±19)N,P＜0.05].결론 복합소식법제비적ADM가능비취병희보편경괄합작위산수보재료.
Objective To study the value of porcine acellular dermal matrix(ADM) made by complex maceration and Marlex mesh as ventral hernia-repairing material. Methods ADM was made from the full thick skin of the back of swines by complex maceration. The male SD rats were randomly divided into three groups including ventral hernia group(n =7), ADM group(the ventral hernia repaired by ADM, n =28) and Marlex mesh group (the ventral hernia repaired by Marlex mesh group, n = 10). The occurrence of ventral hernia was observed on postoperative 1 week. Six rats were respectively selected from the Marlex group and ADM group and tension resistance at 5weeks after surgery was observed. Results The occurrence of ventral hernia in ADM group and Marlex mesh group was significantly lower than that of ventral hernia group(0.04%, 0.0%, 100.0%, P ＜ 0. 01 ) in postoperative 1week, but there was no difference between ADM group and Marlex mesh group ( P ＞ 0.05 ). Marlex had a significantly higher breaking strength than ADM[(417 ±44)N vs( 111 ±27)N,P ＜0.01]. But 5 weeks after surgery, the tension resistance of ADM-fascial interface was higher than that of the Marlex-fascial [( 103 ± 27 ) N vs(71 ± 19 ) N,P ＜ 0. 05]. Conclusion As a material of repairing ventral hernia, ADM prepared by the complex maceration may be superior to Marlex mesh.
