CAJ | 학술논문

肿瘤耐药性一般认为是因基因突变、扩增或表观遗传改变影响肿瘤细胞药物摄取、代谢或外排造成.肿瘤物理微环境不但影响药物在肿瘤组织中的分布,而且肿瘤微环境自身异质性还将造成肿瘤细胞增殖速度差异和低氧及酸中毒,并影响肿瘤的耐药性.就肿瘤物理微环境特点出发,综述了其与肿瘤耐药性之间的关系,并探讨和展望了通过改善肿瘤物理微环境来提高肿瘤化疗灵敏性的策略及未来的研究方向.
종류내약성일반인위시인기인돌변、확증혹표관유전개변영향종류세포약물섭취、대사혹외배조성.종류물리미배경불단영향약물재종류조직중적분포,이차종류미배경자신이질성환장조성종류세포증식속도차이화저양급산중독,병영향종류적내약성.취종류물리미배경특점출발,종술료기여종류내약성지간적관계,병탐토화전망료통과개선종류물리미배경래제고종류화료령민성적책략급미래적연구방향.
Anticancer drugs resistance is often ascribed to gene mutation,amplification or epigenetic changes that affect the uptake,metabolism or export of drugs at the cell level.Tumor physical microenvironment not only influences the drug distribution but also causes difference in cell proliferation rate and hypoxia or acidosis due to its heterogeneity,which could affect the tumor drug resistance.This review discusses the relationship between cancer physical microenvironment and drug resistance and the strategies for enhancement of the chemotherapy sensitivity through modification of the tumor physical microenvironments,as well as foreground of the research.