CAJ | 학술논문

聚肌胞是一种人工合成的病毒双链RNA模拟物,具有重要的免疫调节功能.聚肌胞主要作用于Toll样受体3(TLR3)、维甲酸诱导基因Ⅰ(RIG-Ⅰ)和骨髓瘤分化相关基因-5(MDA-5)3种胞内受体,分别通过含TIR结构域的接头蛋白诱导干扰素β(TRIF)、干扰素β启动刺激剂激活下游信号转导通路,通过激活人体对肿瘤细胞的天然免疫及获得性免疫,从而发挥重要的抗肿瘤免疫调节作用.在黑色素瘤、乳腺癌、恶性胶质细胞瘤及肺癌等恶性肿瘤中,对聚肌胞肿瘤免疫调节机制的进一步阐明将为肿瘤免疫治疗提供新的策略.
취기포시일충인공합성적병독쌍련RNA모의물,구유중요적면역조절공능.취기포주요작용우Toll양수체3(TLR3)、유갑산유도기인Ⅰ(RIG-Ⅰ)화골수류분화상관기인-5(MDA-5)3충포내수체,분별통과함TIR결구역적접두단백유도간우소β(TRIF)、간우소β계동자격제격활하유신호전도통로,통과격활인체대종류세포적천연면역급획득성면역,종이발휘중요적항종류면역조절작용.재흑색소류、유선암、악성효질세포류급폐암등악성종류중,대취기포종류면역조절궤제적진일보천명장위종류면역치료제공신적책략.
Polyinosinic-polycytidylic acid is a synthetic analog of double-stranded RNA,which plays a vital role in the regulation of immune system.Toll-like receptor 3 ( TLR3 ),melanoma differentiation-associated gene 5 (MAD-5) and retinoic acid inducible gene - Ⅰ ( RIG- Ⅰ ) are the main three intracellular receptors binding to polyinosinic-polycytidylic acid which activates human anti-tumor immune responses including the activation of innate immunity and acquired immunity through TIR-domain-containing adapter-inducing inter feron-β (TRIF) and interferon-β.Thus,polyinosinic-polycytidylic acid plays an important role in regulating anti-tumor immune responses.The immunoregulation mechanisms ofpolyinosinic-polycytidylic acid in melanoma,breast cancer,malignant glioma and lung cancer have been clarified,which will provide new strategies for tumor immunotherapy.