中华神经外科杂志
中華神經外科雜誌
중화신경외과잡지
Chinese Journal of Neurosurgery
2012年
2期
157-161
,共5页
赵明亮%程世翔%刘国龙%涂悦%胡群亮%张赛
趙明亮%程世翔%劉國龍%塗悅%鬍群亮%張賽
조명량%정세상%류국룡%도열%호군량%장새
外伤性脑损伤%癫痫%海马%膜片钳%突触传递
外傷性腦損傷%癲癇%海馬%膜片鉗%突觸傳遞
외상성뇌손상%전간%해마%막편겸%돌촉전체
Traumatic brain injury%Epilepsy%Hippocampus%Patch clamp%Synaptic transmission
目的 在细胞及突触水平探讨外伤后癫痫的发病机制.方法 自由落体致伤法制备大鼠颅脑创伤模型,采用膜片钳技术监测海马CA1区锥体细胞内在电生理特性和局部突触兴奋性的变化.结果 颅脑创伤后,大鼠CA1锥体细胞膜输入阻抗和时间常数增加,动作电位的阈电流降低;给予配对刺激后,海马CA1区兴奋性突触后电流表现为配对脉冲比率的降低及配对脉冲易化向配对脉冲抑制的转变.结论 颅脑创伤后海马CA1区神经元内在兴奋性和突触传递功能增强,这些改变可能是外伤后癫痫发病的重要原因.
目的 在細胞及突觸水平探討外傷後癲癇的髮病機製.方法 自由落體緻傷法製備大鼠顱腦創傷模型,採用膜片鉗技術鑑測海馬CA1區錐體細胞內在電生理特性和跼部突觸興奮性的變化.結果 顱腦創傷後,大鼠CA1錐體細胞膜輸入阻抗和時間常數增加,動作電位的閾電流降低;給予配對刺激後,海馬CA1區興奮性突觸後電流錶現為配對脈遲比率的降低及配對脈遲易化嚮配對脈遲抑製的轉變.結論 顱腦創傷後海馬CA1區神經元內在興奮性和突觸傳遞功能增彊,這些改變可能是外傷後癲癇髮病的重要原因.
목적 재세포급돌촉수평탐토외상후전간적발병궤제.방법 자유락체치상법제비대서로뇌창상모형,채용막편겸기술감측해마CA1구추체세포내재전생리특성화국부돌촉흥강성적변화.결과 로뇌창상후,대서CA1추체세포막수입조항화시간상수증가,동작전위적역전류강저;급여배대자격후,해마CA1구흥강성돌촉후전류표현위배대맥충비솔적강저급배대맥충역화향배대맥충억제적전변.결론 로뇌창상후해마CA1구신경원내재흥강성화돌촉전체공능증강,저사개변가능시외상후전간발병적중요원인.
Objective To explore electrophysiologic mechanisms underlying posttraumatic epilepsy on the cellular and synaptic level.Methods Whole cell voltage - clamp recordings were used to examine intrinsic excitability and evoked synaptic events from CA1 pyramidal cells in slices prepared from fluid percussion injury (FPI) rat at various times after the brain injury.Results We find that CA1 pyramidal cells in FPI rats show:( 1 ) increased membrane input resistance and time constant,and decreased threshold current of action potential,( 2 ) decreased paired - pulse ratio (PPR) and a shift of paired - pulse facilitation (PPF) to paired - pulse depression (PPD),which may suggest increase of presynapse transmitter release probability. Conclusions These findings suggest that there is trauma - induced increased intrinsic excitability and synaptic excitation on the cellular level in the rat hippocampus CA1 following cortical contusion head injury.These alterations may facilitate the progress towards the development of epilepsy.