中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2012年
1期
46-49
,共4页
胡文富%傅先明%钱若兵%季学兵%魏祥品%林彬%伊涛%牛朝诗%汪业汉
鬍文富%傅先明%錢若兵%季學兵%魏祥品%林彬%伊濤%牛朝詩%汪業漢
호문부%부선명%전약병%계학병%위상품%림빈%이도%우조시%왕업한
海洛因成瘾%线索诱发%独立成分分析
海洛因成癮%線索誘髮%獨立成分分析
해락인성은%선색유발%독립성분분석
Heroin addiction%Cue elicitation%Independent component analysis
目的 使用独立成分分析(ICA)法分析功能磁共振(fMRI)数据研究线索诱导因素导致海洛因成瘾者复吸的神经网络. 方法 安徽医科大学附属省立医院神经外科自2010年2月至2010年12月对海洛因成瘾组(n=15,来自安徽省戒毒康复中心)和正常对照组(n=15,来自招募的志愿者)在接受吸毒相关场景视频刺激的同时进行fMRI扫描,然后使用ICA方法对数据进行分析和比较2组受试者脑区的激活情况. 结果 与正常对照组相比,海洛因成瘾组患者双侧前额叶、左前扣带回、双侧后扣带回、左侧顶叶、左侧颞下回的激活降低；双侧伏核、右侧海马以及部分枕叶的激活增强,差异有统计学意义(P＜0.05). 结论 ICA方法是一种有效的任务相关fMRI数据分析方法,海洛因成瘾者学习记忆和奖赏系统相关脑区功能改变是线索诱发复吸的重要原因,主要涉及左前额叶、左顶叶、前后扣带回、海马、伏核等脑区.
目的 使用獨立成分分析(ICA)法分析功能磁共振(fMRI)數據研究線索誘導因素導緻海洛因成癮者複吸的神經網絡. 方法 安徽醫科大學附屬省立醫院神經外科自2010年2月至2010年12月對海洛因成癮組(n=15,來自安徽省戒毒康複中心)和正常對照組(n=15,來自招募的誌願者)在接受吸毒相關場景視頻刺激的同時進行fMRI掃描,然後使用ICA方法對數據進行分析和比較2組受試者腦區的激活情況. 結果 與正常對照組相比,海洛因成癮組患者雙側前額葉、左前釦帶迴、雙側後釦帶迴、左側頂葉、左側顳下迴的激活降低；雙側伏覈、右側海馬以及部分枕葉的激活增彊,差異有統計學意義(P＜0.05). 結論 ICA方法是一種有效的任務相關fMRI數據分析方法,海洛因成癮者學習記憶和獎賞繫統相關腦區功能改變是線索誘髮複吸的重要原因,主要涉及左前額葉、左頂葉、前後釦帶迴、海馬、伏覈等腦區.
목적 사용독립성분분석(ICA)법분석공능자공진(fMRI)수거연구선색유도인소도치해락인성은자복흡적신경망락. 방법 안휘의과대학부속성립의원신경외과자2010년2월지2010년12월대해락인성은조(n=15,래자안휘성계독강복중심)화정상대조조(n=15,래자초모적지원자)재접수흡독상관장경시빈자격적동시진행fMRI소묘,연후사용ICA방법대수거진행분석화비교2조수시자뇌구적격활정황. 결과 여정상대조조상비,해락인성은조환자쌍측전액협、좌전구대회、쌍측후구대회、좌측정협、좌측섭하회적격활강저；쌍측복핵、우측해마이급부분침협적격활증강,차이유통계학의의(P＜0.05). 결론 ICA방법시일충유효적임무상관fMRI수거분석방법,해락인성은자학습기억화장상계통상관뇌구공능개변시선색유발복흡적중요원인,주요섭급좌전액협、좌정협、전후구대회、해마、복핵등뇌구.
Objective To detect the neuronal network activity of specific brain areas in heroin addicts under craving state induced by heroin related cues with independent component analysis (ICA) of functional MRI (fMRI) data. Methods Fifteen heroin addicts,admitted to our hospital from February 2010 to December 2010, and 15 healthy controls were recruited in the case-control study; they were performed whole brain scan with 3.0Tesla MR scanner when being presented with heroin related cues.ICA was performed on these data and their neuronal network activities were compared. Results As compared with those in the controls,the bilateral prefrontal cortex,the left anterior cingulated cortex,the bilateral posterior cingulated cortex, the left inferior temporal gyrus and the left parietal lobe enjoyed obviously decreased activity, while bilateral nucleus accumbens, the right hippocampus, part of the temporal lobe and the occipital lobe enjoyed significantly increased activity (P＜0.05). Conclusion ICA is an advanced approach to identify fMRI data induced by related cues; the specific neuroanatomy mediated to cue-elicited heroin craving mostly locates in the learn-memory system and reward system,which involves the frontal cortex,the parietal lobe,the anterior eingulate,the posterior cingulate,the hippocampus and the nucleus accumbens.
