液晶与显示
液晶與顯示
액정여현시
CHINESE JOURNAL OF LIQUID CRYSTALS AND DISPLAYS
2007年
1期
1-5
,共5页
李韶辉%刘红伟%刘鑫勤%郭章红%史子谦
李韶輝%劉紅偉%劉鑫勤%郭章紅%史子謙
리소휘%류홍위%류흠근%곽장홍%사자겸
1,4-双(2-((4,4'-二烷基联环己)-4-基)乙炔基)芳烃%4,4'-二烷基-4-乙炔基联环己烷%1,4-双((4,4'-二烷基联环己)-4-基)丁二炔%4-乙酰基-4,4'-二烷基-联环己烷%格氏试剂%空阻炔%氧化偶联%二溴代芳烃
1,4-雙(2-((4,4'-二烷基聯環己)-4-基)乙炔基)芳烴%4,4'-二烷基-4-乙炔基聯環己烷%1,4-雙((4,4'-二烷基聯環己)-4-基)丁二炔%4-乙酰基-4,4'-二烷基-聯環己烷%格氏試劑%空阻炔%氧化偶聯%二溴代芳烴
1,4-쌍(2-((4,4'-이완기련배기)-4-기)을결기)방경%4,4'-이완기-4-을결기련배기완%1,4-쌍((4,4'-이완기련배기)-4-기)정이결%4-을선기-4,4'-이완기-련배기완%격씨시제%공조결%양화우련%이추대방경
1,4-bis( 2-( ( 4,4'-dialkyl-bicyclohex)-4-yl ) ethynyl) arene%4,4'-dialkyl-4-ethynyl-bicyclohexyl%1,4-bis (( 4,4'-dialkyl-bicyclohex)-4-yl) butadiyne%4-aceto-4,4'-dialkylbicyclohexyl%Grignard reagent%hindered acetylene%oxidative coupling%aryldibr
4,4'-二烷基-4-乙炔基联环己烷(1)和它的偶联衍生物1,4-双((4,4'-二烷基-联环己)-4-基)丁二炔(2)、1,4-双(2-((4,4'-二烷基-联环己)-4-基)乙炔基)芳烃(3)是具有某种特性的重要液晶化合物.文章介绍了以4,4'-二烷基联环己基-4-甲腈(4)为起始原料的化合物的合成.首先,化合物(4)与甲基锂发生加成反应,水解后制得关键中间体甲基酮化合物(5),接着甲基酮化合物(5)与格氏试剂在特定的条件下反应,高收率地制得炔类化合物(1),关于本反应可能的机理文中也进行了阐述.化合物(1)通过氧化自偶联制得化合物(2).化合物(1)与二卤代芳烃在Pd(0)催化系统下发生偶联制得化合物3,这些化合物的制备具有短的合成步骤和高的反应收率,是高效的合成方法;其中化合物(1)的制备方法从未见诸于以前的任何文献报道.
4,4'-二烷基-4-乙炔基聯環己烷(1)和它的偶聯衍生物1,4-雙((4,4'-二烷基-聯環己)-4-基)丁二炔(2)、1,4-雙(2-((4,4'-二烷基-聯環己)-4-基)乙炔基)芳烴(3)是具有某種特性的重要液晶化閤物.文章介紹瞭以4,4'-二烷基聯環己基-4-甲腈(4)為起始原料的化閤物的閤成.首先,化閤物(4)與甲基鋰髮生加成反應,水解後製得關鍵中間體甲基酮化閤物(5),接著甲基酮化閤物(5)與格氏試劑在特定的條件下反應,高收率地製得炔類化閤物(1),關于本反應可能的機理文中也進行瞭闡述.化閤物(1)通過氧化自偶聯製得化閤物(2).化閤物(1)與二滷代芳烴在Pd(0)催化繫統下髮生偶聯製得化閤物3,這些化閤物的製備具有短的閤成步驟和高的反應收率,是高效的閤成方法;其中化閤物(1)的製備方法從未見諸于以前的任何文獻報道.
4,4'-이완기-4-을결기련배기완(1)화타적우련연생물1,4-쌍((4,4'-이완기-련배기)-4-기)정이결(2)、1,4-쌍(2-((4,4'-이완기-련배기)-4-기)을결기)방경(3)시구유모충특성적중요액정화합물.문장개소료이4,4'-이완기련배기기-4-갑정(4)위기시원료적화합물적합성.수선,화합물(4)여갑기리발생가성반응,수해후제득관건중간체갑기동화합물(5),접착갑기동화합물(5)여격씨시제재특정적조건하반응,고수솔지제득결류화합물(1),관우본반응가능적궤리문중야진행료천술.화합물(1)통과양화자우련제득화합물(2).화합물(1)여이서대방경재Pd(0)최화계통하발생우련제득화합물3,저사화합물적제비구유단적합성보취화고적반응수솔,시고효적합성방법;기중화합물(1)적제비방법종미견제우이전적임하문헌보도.
4,4'-dialkyl-4-ethynylbicyclohexyl (1) and their coupled derivatives 1,4-bis ( ( 4,4'-dialkyl-bicyclohex)-4-yl) butadiyne (2), 1,4-bis ( 2-( ( 4,4'-dialkyl-bicyclohex)-4 yl ) ethynyl )arene(3) are very important liquid crystal compounds with some special characters. In this paper, the preparations of these compounds were developed in which 4,4'-dialkylbicyclohexyl-4-carbonitrile(4) is used as the starting material. Firstly, key intermediate 4-aceto-4,4'-dial-kyl-bicyclohexyl (5) was synthesized in good yield through the addition of methyl lithium to compound 4 followed by hydrolyzation, Then, the compound 1 was prepared in excellent yield through the reaction of compound 5 with Grignard reagent whose presumed mechanism was proposed. Acetylene compound 2 was synthesized through the oxidative self-coupling of compound 1, and the preparation of acetylene compound 3 was advanced through the coupling of compound 1 with aryldibromide in the Pd(0) catalyst system. These preparations have high yields and short procedure which are high efficient synthesis methods, and the preparation method of compound 1 is never reported in any literatures heretofore.
