CAJ | 학술논문

目的探讨周围型非小细胞肺癌的CT征象、预后与CD44v3、CD44v6表达的相关性.方法经手术病理证实的46例周围型NSCLC患者进入研究.利用免疫组化SP法检测CD44v3、CD44v6在肺癌组织中的表达,分析其与肺癌CT征象及预后的关系. 结果 CD44v3、CD44v6表达与肺癌CT征象中的深分叶征、棘突征、短毛刺征及肺门、纵隔淋巴结增大密切相关(P＜0.05),与肿瘤大小、空泡征、血管集束征及胸膜凹陷征无明显相关性(P＞0.05);CD44v3、CD44v6表达与肺癌术后3年生存率密切相关(P＜0.05). 结论深分叶征、棘突征、短毛刺征及肺门、纵隔淋巴结增大与CD44v3、CD44v6表达明显相关,提示肺癌的侵袭、转移能力较强;CD44v3、CD44v6阳性表达的肺癌患者术后生存时间更短,预后更差.
목적 탐토주위형비소세포폐암적CT정상、예후여CD44v3、CD44v6표체적상관성.방법 경수술병리증실적46례주위형NSCLC환자진입연구.이용면역조화SP법검측CD44v3、CD44v6재폐암조직중적표체,분석기여폐암CT정상급예후적관계. 결과 CD44v3、CD44v6표체여폐암CT정상중적심분협정、극돌정、단모자정급폐문、종격림파결증대밀절상관(P＜0.05),여종류대소、공포정、혈관집속정급흉막요함정무명현상관성(P＞0.05);CD44v3、CD44v6표체여폐암술후3년생존솔밀절상관(P＜0.05). 결론 심분협정、극돌정、단모자정급폐문、종격림파결증대여CD44v3、CD44v6표체명현상관,제시폐암적침습、전이능력교강;CD44v3、CD44v6양성표체적폐암환자술후생존시간경단,예후경차.
Objective To observe the relationship between CT signs, prognosis and the expression of CD44v3 and CD44v6 in peripheral non-small-cell lung cancer (NSCLC). Methods The expression of CD44v3 and CD44v6 was detected with immunohistochemistry (SP method) in 46 patients with peripheral NSCLC confirmed by surgery and pathology. The expression, CT signs and prognosis of NSCLC were analyzed respectively. Results The expression of CD44v3 and CD44v6 correlated with deep lobulation, spinous protuberant sign, short spiculation and lymph node enlargement of hila or mediastinum (P<0.05), but not with the tumor size, vacuole sign, vessel convergence sign and pleural indentation in CT images of peripheral NSCLC (P＞0.05). The expression of CD44v3 and CD44v6 correlated with the three-year survival rate in peripheral NSCLC patients (P<0.05). Conclusion Deep lobulation, spinous protuberant sign, short spiculation and lymph node enlargement of hila or mediastinum may indicate strong potential invasion and metastasis in peripheral NSCLC. The positive expression of CD44v3 and CD44v6 may suggest shorter survival time and poorer prognosis in peripheral NSCLC patients.