CAJ | 학술논문

目的：探讨氨甲环酸对全髋关节置换围手术期失血量的影响及安全性。方法：选择行单侧全髋关节置换术的85例患者，将其随机分为两组，氨甲环酸组采用切开皮肤前将氨甲环酸1 g稀释于250ml生理盐水静脉滴注，对照组不给予氨甲环酸。比较两组术中出血量、术后引流量、总失血量及术后下肢深静脉栓塞及肺栓塞的发生率。结果：氨甲环酸组和对照组术中出血量分别为（290.3±20.7）ml 和（310.4±23.4）ml，两组比较差异无统计学意义（P＞0.05）。氨甲环酸组和对照组术后引流量分别为（463.5±34.5）ml 和（675.3±36.7）ml，两组比较差异有统计学意义（ P＜0.05）。氨甲环酸组和对照组总失血量分别为（980.6±28.2）ml 和（1250.3±26.7）ml，两组比较差异有统计学意义（ P＜0.05）。术后两组无下肢深静脉栓塞及无肺栓塞发生。结论：全髋关节置换围手术期使用氨甲环酸能明显降低手术失血量，并且不增加静脉血栓及肺栓塞形成的风险。
목적：탐토안갑배산대전관관절치환위수술기실혈량적영향급안전성。방법：선택행단측전관관절치환술적85례환자，장기수궤분위량조，안갑배산조채용절개피부전장안갑배산1 g희석우250ml생리염수정맥적주，대조조불급여안갑배산。비교량조술중출혈량、술후인류량、총실혈량급술후하지심정맥전새급폐전새적발생솔。결과：안갑배산조화대조조술중출혈량분별위（290.3±20.7）ml 화（310.4±23.4）ml，량조비교차이무통계학의의（P＞0.05）。안갑배산조화대조조술후인류량분별위（463.5±34.5）ml 화（675.3±36.7）ml，량조비교차이유통계학의의（ P＜0.05）。안갑배산조화대조조총실혈량분별위（980.6±28.2）ml 화（1250.3±26.7）ml，량조비교차이유통계학의의（ P＜0.05）。술후량조무하지심정맥전새급무폐전새발생。결론：전관관절치환위수술기사용안갑배산능명현강저수술실혈량，병차불증가정맥혈전급폐전새형성적풍험。
Objective To investigate tje efficacy and safety of tranexamic acid on blood loss associated witj total jip artjroplasty ( THA). Method 85 patients underwent THA witj unilateral jip were cjosen. Tjey were randomly divided into Group A and B. In Group A,1 g of tranexamic acid dissolved in 250 ml of normal saline was intravenously infused;in Group B tjere is no influenced factor of tranex-amic acid. Intraoperative blood loss,postoperative drainage,total blood loss,postoperative deep venous tjrombosis and tje incidence of pul-monary embolism were conpared between two goups. Results Tjere were no significant differences between group A(290. 3 ± 20. 7 ml)and Group B(310. 4 ±23. 4 ml)about tje amounts of blood loss in operation(P>0. 05). Tjere were significant differences in tje amount of drainage and gross blood loss of tje THA(P<0. 05 ),tje volume of drainage were(463. 5 ± 34. 5)ml in group A and(675. 3 ± 36. 7)ml in Group B,and tje volume of gross blood loss of tje THA in group A and B was(980. 6 ± 28. 2)ml and(1 250. 3 ± 26. 7)ml respective-ly. Deep vein tjrombosis and pulmonary embolism were not found 6 weeks after operation. Conclusion Tje use of tranexamic acid can sig-nificantly decrease blood loss witjout increasing risk for venous tjrombosis during tje THA .