CAJ | 학술논문

不稳定编码区(CRD)是影响癌基因c-myc的因素之一,CRD结合蛋白(CRD-BP)可通过与c-myc mRNA的CRD相连接,通过保护CRD免受内核酸酶攻击而阻止c-myc mRNA快速降解,延长c-myc mRNA半衰期,进而增加c-myc蛋白含量.人垂体瘤转化基因(hPTTG)具有转化功能,参与细胞周期的调控,调节c-myc基因的表达,与c-myc协同参与结直肠癌的发生、发展及侵袭进程.CRD-BP和hPTTG1的表达与结直肠癌的发生发展可能呈正相关,两者可能对结直肠癌的侵袭转移起协同作用.
불은정편마구(CRD)시영향암기인c-myc적인소지일,CRD결합단백(CRD-BP)가통과여c-myc mRNA적CRD상련접,통과보호CRD면수내핵산매공격이조지c-myc mRNA쾌속강해,연장c-myc mRNA반쇠기,진이증가c-myc단백함량.인수체류전화기인(hPTTG)구유전화공능,삼여세포주기적조공,조절c-myc기인적표체,여c-myc협동삼여결직장암적발생、발전급침습진정.CRD-BP화hPTTG1적표체여결직장암적발생발전가능정정상관,량자가능대결직장암적침습전이기협동작용.
Coding region instability determinant (CRD) is one of the factors of oncogene c-myc. CRD binding protein (CRD-BP) can connect with the c-myc mRNA CRD, through the protection of CRD from nuclease attack within the c-myc mRNA to prevent rapid degradation, thus the stability of c-myc mRNA, the extension of its half-life, thereby increasing c-myc protein content. Human pituitary tumor transforming gene (hPTTG) with conversion features,participates in cell cycle regulation, regulation of c-myc gene expression, and c-myc synergies involved in the occurrence of colorectal cancer, devel-opment and invasive process. CRD-BP and hPTTG1 expression and the occurrence and development of colorec-tal cancer may be a positive correlation between the two possible invasion and metastasis of cancer. The expres-sion of beth sides is were reviewed.