CAJ | 학술논문

杀伤性T细胞(CTL)是病毒感染过程中主要的效应细胞.在急性病毒性感染中,CTL细胞通过杀伤病毒感染的细胞,分泌抗病毒细胞因子从而有效清除病毒.而在慢性病毒感染过程中,病毒特异性CTL发生克隆耗竭,细胞数量少,细胞功能受损,分泌细胞因子能力下降.目前证明,CD28家族成员Programmed Death-1(PD-1)是一种重要的细胞表面分子,能够抑制CTL细胞功能,参与外周免疫耐受,维持T细胞克隆耗竭,保护机体不受免疫病理损伤.在慢性病毒性感染中,T细胞表面的PD-1与其受体PD-L1/2结合后,传递抑制性信号,下调外周T细胞功能.阻断PD-1通路,能够重建CD8+T细胞功能,抑制病毒复制,促进病毒清除.因此,通过干扰PD-1/PD-L1抑制途径进行免疫调节,可能是处理慢性病毒感染性疾病的一个新方法.
살상성T세포(CTL)시병독감염과정중주요적효응세포.재급성병독성감염중,CTL세포통과살상병독감염적세포,분비항병독세포인자종이유효청제병독.이재만성병독감염과정중,병독특이성CTL발생극륭모갈,세포수량소,세포공능수손,분비세포인자능력하강.목전증명,CD28가족성원Programmed Death-1(PD-1)시일충중요적세포표면분자,능구억제CTL세포공능,삼여외주면역내수,유지T세포극륭모갈,보호궤체불수면역병리손상.재만성병독성감염중,T세포표면적PD-1여기수체PD-L1/2결합후,전체억제성신호,하조외주T세포공능.조단PD-1통로,능구중건CD8+T세포공능,억제병독복제,촉진병독청제.인차,통과간우PD-1/PD-L1억제도경진행면역조절,가능시처리만성병독감염성질병적일개신방법.
Cytotoxic T lymphocyte(CTL)is the most important effector cell type for the control of viral in-fection.In acute infection.specific CTLs effectively contribute to the viral clearance by destruction of virus infected ceUs and producton of antiviral cytokines.However,specific CTLs may be exhausted daring chronic viral infections with impaired functions like suppressed cytokine predutions.Recent studies demonstrated that Programmed Death-1(PD-1),a member of CD28 family,is an important factor that inhibits the function of CTLs and plays a role in the peripheral immunological tolerance.It takes part in the maintenance of T cell exhaustion and protects the host against immunopathegenesis.T-cells receive a negative signal when engaged with the PD-L1 ligand on the APC.This mechanism is responsible for the down-regulation of T-cell functions in the periphery during chronic viral infections.By blocking the PD-1/PD-L1 pathway.the function of CD8+ T cell could be restored,leading to the suppression of viral replication in chronically infected hosts.Thus,the immunomodulation by interfering with PD-1/PD-L1 pathway represents a new way to treat chronic viral infections.