CAJ | 학술논문

目的探讨早孕期超声测量胎盘厚度对评价胎儿重型α地中海贫血风险性的价值.方法对208例具有α地中海贫血风险的早孕期胎儿和对照组52例正常胎儿行二维超声检查,测量胎盘厚度.胎盘厚度用中位数的倍数( MOM)表示.结果早孕期重型α地中海贫血胎儿胎盘厚度明显高于中间型、轻型α地中海贫血胎儿和正常胎儿,差异有统计学意义(P＜0.001);其他各组胎盘厚度两两比较,差异无统计学意义(P=0.100).α地中海贫血高危胎儿胎盘厚度提示重型α地中海贫血风险性高的最佳临界点为 1.18 MOM.胎盘厚度>1.18 MOM提示重型α地中海贫血风险性高的灵敏度、特异度分别为 82.9%,84.7%.结论胎盘厚度是评价胎儿患重型α地中海贫血风险性的一项安全、有效的指标,可以减少不必要的侵入性操作,提高重型α地中海贫血胎儿检出率.
목적 탐토조잉기초성측량태반후도대평개태인중형α지중해빈혈풍험성적개치.방법 대208례구유α지중해빈혈풍험적조잉기태인화대조조52례정상태인행이유초성검사,측량태반후도.태반후도용중위수적배수( MOM)표시.결과 조잉기중형α지중해빈혈태인태반후도명현고우중간형、경형α지중해빈혈태인화정상태인,차이유통계학의의(P＜0.001);기타각조태반후도량량비교,차이무통계학의의(P=0.100).α지중해빈혈고위태인태반후도제시중형α지중해빈혈풍험성고적최가림계점위 1.18 MOM.태반후도>1.18 MOM제시중형α지중해빈혈풍험성고적령민도、특이도분별위 82.9%,84.7%.결론 태반후도시평개태인환중형α지중해빈혈풍험성적일항안전、유효적지표,가이감소불필요적침입성조작,제고중형α지중해빈혈태인검출솔.
Objective To investigate the values of ultrasound measuring of the placenta thickness on evaluation of risks for alpha-thalassemia at the early pregnancy.Methods Two-dimensional ultrasound was performed to measure the thickness of placenta on 208 cases of fetuses with alpha-thalassemia and 52 cases of normal fetuses in control group.The placenta thickness was expressed as multiples of the median(MOM).Results At the early pregnancy,the group of fetuses with alpha-thalassemia had significantly higher placenta thickness compared to the fetuses without alpha-thalassemia(P＜0.001).However,there were no statistical significant difference in the placenta thickness between the other groups(P=0.100).Placenta thickness 1.18 MOM was the best critical point to predict alpha-thalassemia.The sensitivity and specificity of placenta thickness >1.18 MOM in prediction of alpha-thalassemia was 82.9%,84.7% respectively.Conclusions For those with high risks of alpha-thalassemia placenta thickness measuring is a safe,effective parameter for assessment because it could reduce unnecessary invasive procedures and improve the detecting rate of severe alpha-thalassemia.