CAJ | 학술논문

目的探讨标准化变应原皮肤点刺试验及免疫治疗在变应性疾病中的临床应用.方法对1836例拟诊变态反应性疾病患者用30种阿罗格变应原进行皮肤点刺试验,以生理盐水为阴性对照,组胺为阳性对照.对466例变应性鼻炎患者,应用屋尘螨、粉尘螨及混合螨变应原进行特异性免疫治疗,追踪观察疗效,对相关资料进行统计分析.结果 1836例拟诊变应性疾病患者中,1322例阳性(72.0%),其中屋尘螨、粉尘螨的阳性率最高,分别为56.4%和53.2%;标准化变应原免疫治疗持续性变应性鼻炎有效率为86.9%(405/466),无明显不良反应.结论阿罗格变应原皮肤点刺试验安全、敏感、准确,为变应性疾病的诊治提供重要依据;标准化变应原免疫治疗能有效缓解或减轻变应性鼻炎患者的症状,且疗效高、操作简便、不良反应少.
목적 탐토표준화변응원피부점자시험급면역치료재변응성질병중적림상응용.방법 대1836례의진변태반응성질병환자용30충아라격변응원진행피부점자시험,이생리염수위음성대조,조알위양성대조.대466례변응성비염환자,응용옥진만、분진만급혼합만변응원진행특이성면역치료,추종관찰료효,대상관자료진행통계분석.결과 1836례의진변응성질병환자중,1322례양성(72.0%),기중옥진만、분진만적양성솔최고,분별위56.4%화53.2%;표준화변응원면역치료지속성변응성비염유효솔위86.9%(405/466),무명현불량반응.결론 아라격변응원피부점자시험안전、민감、준학,위변응성질병적진치제공중요의거;표준화변응원면역치료능유효완해혹감경변응성비염환자적증상,차료효고、조작간편、불량반응소.
Objective To observe the clinical application of the standardized skin insertion test andimmunotherapy in allergic disease.Methods Thirty different allergens produced by Germany AllergophamaCompany were applied in skin insertion test.The test using normal saline was set up as a negative control group,with a positive control group using Histamine.Meanwhile 466 allergic rhinitis patients were treated by specificimmunotherapy(SIT)with Dermatophagoides pteronyssinus and Dermatophagoides farinae.Results Among 1836cases,1322(72.0%)had positive results. Among them,the Dermatophagoides pteronyssinus andDermatophagoides farinae showed tlle highest positive rates(56.4%,53.2%).The effective rate of standardizedallergen immunotherapy for treating persistent allergic rhinitis was 86.9%(405/466),with no complicationobserved.Conclusion Allergen skin insertion tests appears accurate,sensitive and safe,which is valuable fordiagnosis and therapy of allergic diseases.The standardized allergen immunotherapy can effectively and safely relievesymptoms of allergic rhinitis patients.