CAJ | 학술논문

目的探讨沙美特罗/氟替卡松对慢性阻塞性肺疾病(COPD)患者气道炎症的影响.方法选择40例COPD急性加重期患者,随机分成沙美特罗/氟替卡松治疗组(A组)和对照组(B组),并选择18例健康人作为健康对照组(C组).观察其支气管肺泡灌洗液(BALF)中自细胞介素8(IL-8)和肿瘤坏死因子α(TNF-α)的变化.结果 A组和B组患者BAL中[IL-8(10.60±1.42)μg/L,(10.77±1.98)μg/L]及TNF-α含量[(14.80±2.05)μg/L,(14.70±2.03)μg/L]均高于C组[(3.40±0.65)μg/L,(4.67±1.01)μg/L](均P<0.01);治疗前BALF中IL-8与TNF-α含量,A组[(10.60±1.42)μg/L,(14.80±2.05)μg/L]和B组[(10.77±1.98)μg/L,(14.70±2.03)μg/L]差异均无统计学意义(均P>0.05),但治疗两周后,A组BALF中IL-8及TNF-α含量[(4.39±0.92)μg/L,(5.84±1.26)μg/L]较B组[(9.69±1.43)μg/L,(12.88±2.51)μg/L]均明显下降(均P<0.01).结论沙美特罗/氟替卡松可以有效控制COPD患者的气道炎症.
목적 탐토사미특라/불체잡송대만성조새성폐질병(COPD)환자기도염증적영향.방법 선택40례COPD급성가중기환자,수궤분성사미특라/불체잡송치료조(A조)화대조조(B조),병선택18례건강인작위건강대조조(C조).관찰기지기관폐포관세액(BALF)중자세포개소8(IL-8)화종류배사인자α(TNF-α)적변화.결과 A조화B조환자BAL중[IL-8(10.60±1.42)μg/L,(10.77±1.98)μg/L]급TNF-α함량[(14.80±2.05)μg/L,(14.70±2.03)μg/L]균고우C조[(3.40±0.65)μg/L,(4.67±1.01)μg/L](균P<0.01);치료전BALF중IL-8여TNF-α함량,A조[(10.60±1.42)μg/L,(14.80±2.05)μg/L]화B조[(10.77±1.98)μg/L,(14.70±2.03)μg/L]차이균무통계학의의(균P>0.05),단치료량주후,A조BALF중IL-8급TNF-α함량[(4.39±0.92)μg/L,(5.84±1.26)μg/L]교B조[(9.69±1.43)μg/L,(12.88±2.51)μg/L]균명현하강(균P<0.01).결론 사미특라/불체잡송가이유효공제COPD환자적기도염증.
Objective To investigate the influence of salmeterol with fluticasone on airway inflammation of patients with acute exacerbation chronic obstructive pulmonary disease (COPD).Methods 40 COPD patients in the stage of acute exacerbation were randomly divided into salmeterol with fluticasone group( A group) and controll group (B group).Bronchial alveolar lavage( BAL) was performed as usual.The concentrations of IL-8 and TNF-α in bronchial alveolar lavage fluid(BALF) were measured by ELISA.The results were compared with that of 18 healthy volunteers.Results The levels of IL-8 and TNF-a in BALF of patients in A group(10.60 ± 1.42) μg/L, (14.80 ± 2.05) μg/Land B group( 10.77 ± 1.98) μg/L, (14.70 ± 2.03) μg/L were significantly higher than that of C group (3.40 ±0.65)μg/L, (4.67 ± 1.01) μg/L( all P <0.01) ;Before treatment,the levels of IL-8 and INF-α in BALF of A group( 10.60 ± 1.42)μg/L,(14.80 ±2.05) μg/L and B group( 10.77 ± 1.98) μg/L,(14.70 ±2.03) μg/L had no significant differences (all P > 0.05) ,and the concentrations of IL-8 and TNF-a in BALF in group A (4.39 ± 0.92)μg/L,(5.84 ±1.26) μg/L were significantly lower than that in group B(9.69 ± 1.43) μg/L, (12.88 ± 2.51) μg/L after two weeks treatment ( all P < 0.01).Conclusion Salmeterol with fluticasone could inhibit airway inflammation of COPD patients in the stage of acute exacerbation.