CAJ | 학술논문

目的探讨5-羟色胺(5-HT)2A受体T102C基因多态性与卒中后抑郁(PSD)的关系,研究PSD的遗传发病机制.方法选择珠江医院神经内科自2010年1月至2010年12月收治的汉族住院患者为研究对象,根据有无并发抑郁症将其分为PSD组(97例)及单纯卒中组(72例).采用PCR和限制性片断长度多态性(RFLP)技术测定2组患者5-HT2A受体T102C等位基因频率及基因型.结果 PSD组中突变型C等位基因频率(43.3％)低于单纯脑卒中组(59.0％),突变纯合子C/C基因型频率(20.6％)也低于单纯卒中组(34.7％),差异均有统计学意义(x2=0.179,P=0.004；x2=7.855,P=0.020).结论 5-HT2A受体T102C基因可能是PSD的易感基因,C等位基因是罹患PSD的保护因子.
목적 탐토5-간색알(5-HT)2A수체T102C기인다태성여졸중후억욱(PSD)적관계,연구PSD적유전발병궤제.방법 선택주강의원신경내과자2010년1월지2010년12월수치적한족주원환자위연구대상,근거유무병발억욱증장기분위PSD조(97례)급단순졸중조(72례).채용PCR화한제성편단장도다태성(RFLP)기술측정2조환자5-HT2A수체T102C등위기인빈솔급기인형.결과 PSD조중돌변형C등위기인빈솔(43.3％)저우단순뇌졸중조(59.0％),돌변순합자C/C기인형빈솔(20.6％)야저우단순졸중조(34.7％),차이균유통계학의의(x2=0.179,P=0.004；x2=7.855,P=0.020).결론 5-HT2A수체T102C기인가능시PSD적역감기인,C등위기인시리환PSD적보호인자.
Objective To explore the relationship between polymorphism of 5-hydroxy tryptamine 2A(5-HT2A)receptor T102C gene and post-stroke depression(PSD),and investigate the heredity-related pathogenesis of PSD.Methods The polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP)method was applied to test the allele frequencies and genotype of 5-HT2A receptor T102C gene in 97 patients with PSD and 72 patients without depression after stroke.Results The frequency of mutant C allele in patients with PSD was significantly lower than that in patients without depression(P＜0.05),and the frequency of homozygote C/C genotype in patients with PSD was also obviously lower than that in patients without depression(P＜0.05).Conclusion The 5-HT2A receptor T102C gene may be the susceptibility gene of PSD and C allele may be the protective factor of subjects suffering from PSD.