CAJ | 학술논문

目的分析复发和治疗失败患者结核杆菌基因型并进行病原学探讨.方法以2000年1月-2007年12月在北京市结核病胸部肿瘤研究所2次住院相邻时间间隔至少在6个月以上、有分离菌株的肺结核病患者作为研究对象.应用结核分枝杆菌基因分型方法对患者初次和第2次治疗的菌株进行分型并比较.结果 24例结核病患者入选本研究.在完成初次治疗的5人中,其前后分离株的基因型均相同;在另19例患者(8例丢失、11例治疗失败)中,有2例(10.5%)患者其分离株的基因型与第1次不同;其余17例(89.5%)患者前后2次分离株的基因型相同.结论内源发病是复发的主要原因,失败和丢失病例中少数存在再感染情况.
목적 분석복발화치료실패환자결핵간균기인형병진행병원학탐토.방법 이2000년1월-2007년12월재북경시결핵병흉부종류연구소2차주원상린시간간격지소재6개월이상、유분리균주적폐결핵병환자작위연구대상.응용결핵분지간균기인분형방법 대환자초차화제2차치료적균주진행분형병비교.결과 24례결핵병환자입선본연구.재완성초차치료적5인중,기전후분리주적기인형균상동;재령19례환자(8례주실、11례치료실패)중,유2례(10.5%)환자기분리주적기인형여제1차불동;기여17례(89.5%)환자전후2차분리주적기인형상동.결론 내원발병시복발적주요원인,실패화주실병례중소수존재재감염정황.
Objective To analyze the genotypes of M. tuberculosis from the TB patients with recurrence or treatment failure. Methods Tuberculosis (TB) inpatients who had strains isolated from two successive episodes separated for at least 6 months were selected from Beijing Tuberculo-from the patients were analyzed by M. tuberculosis genotyping methods to find out if the profiles matched. Results 24 patients recruited into the study. The genotype patterns of recurrent M. tu-berculosis isolates from the 5 patients previously completed treatment exhibited identical genotypes, indicating endogenous reactivation. Of 19 isolates from 8 patients defaulted from treatment and 11 patients with treatment failure, genotype patterns of 2 isolates (10. 5%) did not match with those of the corresponding initial isolates, indicating reinfection. Isolates from the remaining 17 (89.5%) patients had identical genotype profiles results, suggesting treatment failure. Conclusions The en-dogenous reactivation and treatment failure may be a main cause for the recurrence of TB cases.