国际口腔科学杂志（英文版）
國際口腔科學雜誌（英文版）
국제구강과학잡지（영문판）
INTERNATIONAL JOURNAL OF ORAL SCIENCE
2012年
2期
64-68
,共5页
endochondral ossification%intramembranous ossification%osteogenesis%vascular endothelial growth factor
Osteogenesis and angiogenesis are two closely correlated processes during bone growth, development, remodelling and repair. Vascular endothelial growth factor (VEGF) is an essential mediator during the process of angiogenesis. Based on an extensive literature search, which was carried out using the PubMed database and the keywords of osteogenesis, VEGF, endochondral ossification and intramembranous ossification, this manuscript reviews the role of VEGF in ossification, with emphasis on its effect in endochondral and intramembranous ossification. Osteogenesis and angiogenesis are closely correlated processes. VEGF acts as an essential mediator during these processes. It not only functions in bone angiogenesis but also in various aspects of bone development.
