CAJ | 학술논문

铂类药作为化疗一种关键药之一,被广泛用于治疗各种恶性肿瘤,如卵巢、膀胱、头颈部肿瘤及肺癌.但铂类耐药的发生限制了化疗反应,影响了患者的预后.目前在铂类耐药的机制方面已经有一些重要的发展,其中之一是肿瘤铂类耐药与细胞内浓度的蓄积之间的相关性,摄入的减少和泵出过多均可减少药物在细胞内的聚积,导致耐药.但是具体耐药机制尚不清楚.铜离子动态平衡是由铜离子转运蛋白及其分子伴侣来维持.铜离子转运蛋白家族包括铜离子转运蛋白和铜离子转运磷酸化ATP酶.本文将就铜离子转运蛋白家族与肺癌顺铂耐药作一综述.
박류약작위화료일충관건약지일,피엄범용우치료각충악성종류,여란소、방광、두경부종류급폐암.단박류내약적발생한제료화료반응,영향료환자적예후.목전재박류내약적궤제방면이경유일사중요적발전,기중지일시종류박류내약여세포내농도적축적지간적상관성,섭입적감소화빙출과다균가감소약물재세포내적취적,도치내약.단시구체내약궤제상불청초.동리자동태평형시유동리자전운단백급기분자반려래유지.동리자전운단백가족포괄동리자전운단백화동리자전운린산화ATP매.본문장취동리자전운단백가족여폐암순박내약작일종술.
Cisplatin is one of the most important chemotherapeutic agents,commonly used for treatment of various cancers including ovary,endometrial,lung and gastric cancer.The secondary drugresistance,however,limits the efficacy of chemotherapy and consequently compromises the prognosis of patients.Recently,there have been some important developments in the understanding of mechanisms of tumor resistance to cisplatin.One of them is concerning the association between the tumor resistance to platinum drugs and the reduced intracellular accumulation owing to impaired drug intake and enhanced outward transport.However,mechanisms for transporting platinum drugs were not known until recently studies have shown that copper transporters may be involved in the transport of platinum-based anticancer drugs.Body copper homeostasis is maintained by a group of proteins including copper transporters and chaperones.Copper transporters include copper transporter 1 and copper-transporting P-type adenosine triphosphatase.This paper will state copper ion transport protein family and cisplatin drug resistance in lung cancer.