中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
24期
3363-3365
,共3页
急性冠脉综合征%高敏C反应蛋白%白介素-6%相关性
急性冠脈綜閤徵%高敏C反應蛋白%白介素-6%相關性
급성관맥종합정%고민C반응단백%백개소-6%상관성
Acute coronary syndrome%High-sensitivity C-reactive protein%Interleukin-6%Correlation
目的 探讨炎性标志物高敏C反应蛋白(hs-CRP)、白介素-6(IL-6)与急性冠脉综合征(ACS)的关系.方法 对60例ACS[其中急性心肌梗死(AMI)33例,不稳定型心绞痛(UAP)27例]和45例稳定型心绞痛(SAP)患者及45例健康人群,采用免疫透射比浊法检测血清hs-CRP水平,酶联免疫吸附法(ELISA)检测血清IL-6水平,比较各组的差异及其在ACS中的相互关系.结果 ACS组血清hs-CRP、IL-6浓度明显高于SAP组及健康对照组(P＜0.01),其中,AMI组血清hs-CRP、IL-6浓度又明显高于UAP组,差异有统计学意义(P＜0.05);ACS患者血清hs-CRP与IL-6呈正相关(r=0.836).结论 血清hs-CRP、IL-6水平可判断斑块的稳定性,且在ACS过程中具有一定的相关性,对ACS预后的判断具有重要价值.
目的 探討炎性標誌物高敏C反應蛋白(hs-CRP)、白介素-6(IL-6)與急性冠脈綜閤徵(ACS)的關繫.方法 對60例ACS[其中急性心肌梗死(AMI)33例,不穩定型心絞痛(UAP)27例]和45例穩定型心絞痛(SAP)患者及45例健康人群,採用免疫透射比濁法檢測血清hs-CRP水平,酶聯免疫吸附法(ELISA)檢測血清IL-6水平,比較各組的差異及其在ACS中的相互關繫.結果 ACS組血清hs-CRP、IL-6濃度明顯高于SAP組及健康對照組(P＜0.01),其中,AMI組血清hs-CRP、IL-6濃度又明顯高于UAP組,差異有統計學意義(P＜0.05);ACS患者血清hs-CRP與IL-6呈正相關(r=0.836).結論 血清hs-CRP、IL-6水平可判斷斑塊的穩定性,且在ACS過程中具有一定的相關性,對ACS預後的判斷具有重要價值.
목적 탐토염성표지물고민C반응단백(hs-CRP)、백개소-6(IL-6)여급성관맥종합정(ACS)적관계.방법 대60례ACS[기중급성심기경사(AMI)33례,불은정형심교통(UAP)27례]화45례은정형심교통(SAP)환자급45례건강인군,채용면역투사비탁법검측혈청hs-CRP수평,매련면역흡부법(ELISA)검측혈청IL-6수평,비교각조적차이급기재ACS중적상호관계.결과 ACS조혈청hs-CRP、IL-6농도명현고우SAP조급건강대조조(P＜0.01),기중,AMI조혈청hs-CRP、IL-6농도우명현고우UAP조,차이유통계학의의(P＜0.05);ACS환자혈청hs-CRP여IL-6정정상관(r=0.836).결론 혈청hs-CRP、IL-6수평가판단반괴적은정성,차재ACS과정중구유일정적상관성,대ACS예후적판단구유중요개치.
Objective To investigate the relationship among the inflammatory markers of high-sensitivity Creactive protein(hs-CRP), interleukin-6 (IL-6) and the process of the acute coronary syndrome (ACS).Methods Immunity turbidimetry assay was used to test the serum hs-CRP,and enzyme linked immunosorbent assay (ELISA) was used to test the serum IL-6 in 60 ACS cases[33 cases with acute myocardial infarction(AMI) ,27 cases with unstable angina pectoris(UAP)],45 cases with stable angina pectoris (SAP)and 45 healthy persons. The differences of the serum hs-CRP and the serum IL-6 were compared among the three groups and the correlation between serum hs-CRP and the serum IL-6 was also analyzed in the ACSs. Results The concentrations of the serum hs-CRP and the serum IL-6 in ACSs were both significantly higher than those of SAPs and healthy persons (all P＜0.01).The concentrations of the serum hs-CRP and the serum IL-6 in AMIs were significantly higher than those of UAPs (all P＜0.05). And there was a direct correlation between the serum hs-CRP and the serum IL-6 in ACSs (r=0.836).Conclusion The levels of the serum hs-CRP and the serum IL-6 could be used to judge the stability of the plaques,and there was some direct correlation between them in the ACS process, and they should he valuable to predict the prognosis of ACSs.
