CAJ | 학술논문

分析本院22例胃肠道间质瘤患者的临床资料.主要临床表现为消化道出血(14/22)、腹部不适(5/22)及包块(3/22).病变部位多见于胃(14/22).22例均行手术治疗,术后病理结果证实良性病例占多数(12/22).免疫组化酪氨酸激酶受体117(CD117)(+)73%,造血干细胞抗原(CD34)(+)73%,平滑肌肌动蛋白(-)73%,可溶性酸性蛋白(-)68%.随访至术后1～5年者18例,3例死亡.在行完全切除术的所有病例中,影响术后生存率的因素经多因素Cox回归分析显示与肿瘤大小、性质及是否复发转移密切相关.本病临床表现无特异性,术前确诊困难,手术切除是病理确诊和治疗的主要方法.
분석본원22례위장도간질류환자적림상자료.주요림상표현위소화도출혈(14/22)、복부불괄(5/22)급포괴(3/22).병변부위다견우위(14/22).22례균행수술치료,술후병리결과증실량성병례점다수(12/22).면역조화락안산격매수체117(CD117)(+)73%,조혈간세포항원(CD34)(+)73%,평활기기동단백(-)73%,가용성산성단백(-)68%.수방지술후1～5년자18례,3례사망.재행완전절제술적소유병례중,영향술후생존솔적인소경다인소Cox회귀분석현시여종류대소、성질급시부복발전이밀절상관.본병림상표현무특이성,술전학진곤난,수술절제시병리학진화치료적주요방법.
The clinical data of 22 cases with gastrointestinal stromal tumors were retrospectively analized.The main clinical manifestations were gastrointestinal bleeding (14/22),abdominal discomfort (5/22) and abdominal lump (3/22),stomach was the most common site of the tumor (14/22).All 22 cases underwent surgical treatment and pathological examination confirmed that 12 cases were benign.Immunohistochemical results showed that 68% cases were negative in solubility acid protein-100 (S-100),and the positive rates of tyrosine-protein kinase acceptor 117 (CD117),hemopoietic stem cell antigen 34 (CD34) and negative rate of smooth muscle actin (SMA) were all 73%.Eighteen cases were followed up for 1-5 years after operation,among them 3 died.The survival was closely related to the size,the pathological characteristics and the recurrance of the tumor as demonstrated by multivariate Cox regression analysis.Since gastrointestinal stromal tumor has no specific clinical manifestations,preoperative diagnosis is difficulty,so surgical resection and subsequent pathological examination is used for confirmation of diagnosis,as well as treatment of the disease.