肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2008年
7期
445-448
,共4页
刘尽国%李昊%张洪福%杨枫
劉儘國%李昊%張洪福%楊楓
류진국%리호%장홍복%양풍
肠肿瘤%E钙黏着糖蛋白类%免疫组织化学%预后
腸腫瘤%E鈣黏著糖蛋白類%免疫組織化學%預後
장종류%E개점착당단백류%면역조직화학%예후
Intestinal neoplasms%E-cadherins%Immunohistochemistry%Prognosis
目的 研究S100A4蛋白和上皮钙黏蛋白(E-cad)在大肠癌组织中的表达及其临床意义.方法 应用免疫组织化学SP法检测87例大肠癌组织及癌旁大肠组织中S100A4蛋白和E-cad的表达水平,分析S100A4和E-cad表达与大肠癌临床病理因素及术后5年生存率的关系.结果 在癌旁大肠组织腺上皮中S100A4蛋白不表达;在大肠癌组织中S100A4蛋白的表达率为64.4%(56/87),与癌旁大肠组织比较.差异有统计学意义(P＜0.01);S100A4蛋白在大肠癌组织中的表达与临床分期、淋巴结转移及5年生存率有关(P＜0.05),与其他临床病理因素无关(P＞0.05).在癌旁大肠组织中E-cad100%表达;在大肠癌组织中E-cad的表达率为62.1%(54/87);与癌旁大肠组织比较,差异有统计学意义(P＜0.01);E-cad在大肠癌组织中的表达与临床分期、淋巴结转移、肿块位置及5年生存率有关(P＜0.05).与其他临床病理因素无关(P＞0.05).S100A4蛋白和E-cad在大肠癌组织中的表达呈负相关,但差异无统计学意义(r=-0.087,P＞0.05).结论 S100A4蛋白和E-cad与大肠癌的侵袭、转移及预后密切相关;S100A4蛋白可作为判定大肠癌临床病理特征及判断预后的重要指标.
目的 研究S100A4蛋白和上皮鈣黏蛋白(E-cad)在大腸癌組織中的錶達及其臨床意義.方法 應用免疫組織化學SP法檢測87例大腸癌組織及癌徬大腸組織中S100A4蛋白和E-cad的錶達水平,分析S100A4和E-cad錶達與大腸癌臨床病理因素及術後5年生存率的關繫.結果 在癌徬大腸組織腺上皮中S100A4蛋白不錶達;在大腸癌組織中S100A4蛋白的錶達率為64.4%(56/87),與癌徬大腸組織比較.差異有統計學意義(P＜0.01);S100A4蛋白在大腸癌組織中的錶達與臨床分期、淋巴結轉移及5年生存率有關(P＜0.05),與其他臨床病理因素無關(P＞0.05).在癌徬大腸組織中E-cad100%錶達;在大腸癌組織中E-cad的錶達率為62.1%(54/87);與癌徬大腸組織比較,差異有統計學意義(P＜0.01);E-cad在大腸癌組織中的錶達與臨床分期、淋巴結轉移、腫塊位置及5年生存率有關(P＜0.05).與其他臨床病理因素無關(P＞0.05).S100A4蛋白和E-cad在大腸癌組織中的錶達呈負相關,但差異無統計學意義(r=-0.087,P＞0.05).結論 S100A4蛋白和E-cad與大腸癌的侵襲、轉移及預後密切相關;S100A4蛋白可作為判定大腸癌臨床病理特徵及判斷預後的重要指標.
목적 연구S100A4단백화상피개점단백(E-cad)재대장암조직중적표체급기림상의의.방법 응용면역조직화학SP법검측87례대장암조직급암방대장조직중S100A4단백화E-cad적표체수평,분석S100A4화E-cad표체여대장암림상병리인소급술후5년생존솔적관계.결과 재암방대장조직선상피중S100A4단백불표체;재대장암조직중S100A4단백적표체솔위64.4%(56/87),여암방대장조직비교.차이유통계학의의(P＜0.01);S100A4단백재대장암조직중적표체여림상분기、림파결전이급5년생존솔유관(P＜0.05),여기타림상병리인소무관(P＞0.05).재암방대장조직중E-cad100%표체;재대장암조직중E-cad적표체솔위62.1%(54/87);여암방대장조직비교,차이유통계학의의(P＜0.01);E-cad재대장암조직중적표체여림상분기、림파결전이、종괴위치급5년생존솔유관(P＜0.05).여기타림상병리인소무관(P＞0.05).S100A4단백화E-cad재대장암조직중적표체정부상관,단차이무통계학의의(r=-0.087,P＞0.05).결론 S100A4단백화E-cad여대장암적침습、전이급예후밀절상관;S100A4단백가작위판정대장암림상병리특정급판단예후적중요지표.
Objective To investigate the expression and significance of S100A4 protein and Ecadherin in coloreetal carcinoma. Methods S-P immunohistochemical method was used to detect the expression of S100A4 and E-cadherin in 87cases with colorectal carcinoma and 87 cases with adjacent colorectal tissue, and the expression of S100A4 and E--cadherin were analyzed with relation to clinicopathologic factors and post-operative five-year survival. Results There was no expression for S100A4 protein in glandular epithelium of adjacent colorectal tissues. The positive expression rate of S100A4 was 64.4 %(56/87) in colorectal carcinoma. There was a significant difference between eolorectal carcinoma and adjacent group(P ＜0.01). The expression of S100A4 was positively correlated with the clinical stages, lymph node metastasis and five-year survival (P ＜0.05), but not with other clinicopathalagic factors (P ＞0.05). There was 100 % expression for E-cadherin in adjacent colorectal tissues. The positive expression rate of Ecadherin was 62.1%(54187) in colorectal carcinoma. There was a significant difference between colorectal carcinoma and adjacent group (P ＜0.01). The expression of E-cadherin was positively correlated with the clinical stages, lymph node metastasis, tumor site and five-year survival (P ＜0.05), hut not with other clinicopathologic factors (P ＞0.05). The expression of S100A4 was negatively correlated to E-cadherin in colorectal carcinoma without statistical meaning(r =-0.087, P ＞0.05). Conclusion S100A4 and E-cadherin are closely related with colorectal cancer invasion, metastasis and prognosis; S100A4 might be an important predictor of the clinicopathologic features and prognosis of eolorectal carcinoma.
