CAJ | 학술논문

目的探讨前列腺素E1联合参附注射液对缺血性心肌病患者心力衰竭的疗效.方法选择缺血性心肌病2～4级心功能患者140例,随机分为治疗组80例和对照组60例.治疗组在常规治疗的基础上加用参附注射液和前列腺素E1静脉滴注;对照组仅用常规治疗.治疗前后观察患者症状体征、心功能及血液流变学变化.结果治疗后,治疗组总有效率89%,临床症状体征、心功能及血液流变学等各项指标较治疗前有明显改善(P<0.01),与对照组相比差异有统计学意义(P<0.05或0.01).结论在常规治疗基础上前列腺素E1联合参附注射液治疗缺血性心肌病能迅速提高心脏功能,改善血液流变学,消除临床症状,可广泛用于治疗缺血性心肌病心功能不全患者.
목적 탐토전렬선소E1연합삼부주사액대결혈성심기병환자심력쇠갈적료효.방법 선택결혈성심기병2～4급심공능환자140례,수궤분위치료조80례화대조조60례.치료조재상규치료적기출상가용삼부주사액화전렬선소E1정맥적주;대조조부용상규치료.치료전후관찰환자증상체정、심공능급혈액류변학변화.결과 치료후,치료조총유효솔89%,림상증상체정、심공능급혈액류변학등각항지표교치료전유명현개선(P<0.01),여대조조상비차이유통계학의의(P<0.05혹0.01).결론 재상규치료기출상전렬선소E1연합삼부주사액치료결혈성심기병능신속제고심장공능,개선혈액류변학,소제림상증상,가엄범용우치료결혈성심기병심공능불전환자.
Objective To investigate the effects of Shenfu injection and prostaglantin E1(PGE1) on ischemic cardiomy-opathy with heart failure. Methods 140 patients of ischemic cardiomyopathy with heart failure were randomly divided into thera-py group (80 cases) and control group (60 cases), the patients in therapy group received routine therapy plus intravenous Shen-fu injection and intravenous PGE1 once a day. the patients in control group only received routine therapy. Before and after thera-py, the changes of the cliniel symptoms, the cardiac function, the hematological dynamics were measured. Results The total ef-ficacy rate of therapy group was 89%. In post-treatment,the changes of the clinical symptoms, the cardiac function, and the he-matological dynamics were obviously improved compared with pre-treatment(P<0.01). There was a significant difference in ther-apy group compared with control group (P<0.05 or 0.01). Conclusion Shenfu injection in combination with prostaglandin E1have obvious efficacy intreating the ischemic cardiomyopathy with heart failure.