CAJ | 학술논문

从乌墨(Syzygium cumini)根的甲醇提取物中分离鉴定8个已知化合物,并对其进行了经高糖、高胰岛素处理后胰岛素抵抗L6肌管细胞糖摄取活性的筛选.初步研究结果表明,其中7个化合物在有无胰岛素刺激下均能明显促进葡萄糖的利用.在无胰岛素刺激状态下,浓度为10 μg ml~(-1)时,无羁萜(1)的葡萄糖消耗量比抵抗细胞增加了17.35%;在有胰岛素刺激状态下,浓度为0.1 μg ml~(-1),5, 7, 3′, 4′, 5′-五羟基黄酮(8)葡萄糖消耗量比抵抗细胞增加了51.11%.
종오묵(Syzygium cumini)근적갑순제취물중분리감정8개이지화합물,병대기진행료경고당、고이도소처리후이도소저항L6기관세포당섭취활성적사선.초보연구결과표명,기중7개화합물재유무이도소자격하균능명현촉진포도당적이용.재무이도소자격상태하,농도위10 μg ml~(-1)시,무기첩(1)적포도당소모량비저항세포증가료17.35%;재유이도소자격상태하,농도위0.1 μg ml~(-1),5, 7, 3′, 4′, 5′-오간기황동(8)포도당소모량비저항세포증가료51.11%.
Eight known compounds isolated from the roots of Syzygium cumini were evaluated for their ability to enhance the glucose consumption in insulin-resistant L6 muscle cells induced by high concentration-insulin and glucose. All of compounds significantly enhanced the glucose consumption of insulin-resistant cells in the presence and absence of insulin. The glucose consumption was increased 17.35% and 51.11% by compound 1 (friedelin) at a concentration of 10 μg ml~(-1) without insulin and by compound 8 (5, 7, 3', 4', 5'-pentahydroxyflavone) at a concentration of 0.1 μg ml~(-1) with insulin, respectively.