CAJ | 학술논문

抗原多态性对传染病疫苗研发的影响已引起研究者们的广泛重视.针对某一变异类型的重组蛋白疫苗,其诱导的免疫力往往小能产生对其他变异类型的保护效果.血吸虫基因组研究显示血吸虫存在大量抗原基因的变异,特别是一些与免疫保护相关的抗原基因,其变异程度和频率更高.该文综述了血吸虫重要抗原的多态性及其变异机制和对免疫保护的影响.
항원다태성대전염병역묘연발적영향이인기연구자문적엄범중시.침대모일변이류형적중조단백역묘,기유도적면역력왕왕소능산생대기타변이류형적보호효과.혈흡충기인조연구현시혈흡충존재대량항원기인적변이,특별시일사여면역보호상관적항원기인,기변이정도화빈솔경고.해문종술료혈흡충중요항원적다태성급기변이궤제화대면역보호적영향.
The effects of antigenic polymorphism on vaccine development have been widely investigated.Immunity induced by a specific allele may not be protective against pathogen with another allele.Polymorphism of schistosome antigens has been identified through recent completion of Schistosoma genome project(SGP).Particularly,those antigens that can induce protective immunity have higher level of variations compared to others.This reivew describes variations of some important antigens in schistosome and its effects onvaccine development.