CAJ | 학술논문

目的研究急性一氧化碳中毒迟发脑病(DEACMP)患者脑脊液中兴奋性氨基酸水平的变化及其临床意义.方法采用高效液相色谱(HPLC)法测定24例DEACMP患者(DEACMP组)及20例偏头痛缓解期患者(对照组)脑脊液中兴奋性氨基酸的主要组分谷氨酸(Glu)、天门冬氨酸(Asp)水平.结果 DEACMP组患者脑脊液中Glu、Asp水平高于对照组[(3.76±1.52)μmol/L比(1.55±1.03)μmol/L;(0.73±0.44)μmol/L比(0.38±0.33)μmol/L,P均<0.01],且神经功能缺损程度越重,Glu和Asp水平越高.结论兴奋性氨基酸参与DEACMP病理过程,脑脊液中兴奋性氨基酸水平升高,可能提示早期DEACMP的发生.
목적 연구급성일양화탄중독지발뇌병(DEACMP)환자뇌척액중흥강성안기산수평적변화급기림상의의.방법 채용고효액상색보(HPLC)법측정24례DEACMP환자(DEACMP조)급20례편두통완해기환자(대조조)뇌척액중흥강성안기산적주요조분곡안산(Glu)、천문동안산(Asp)수평.결과 DEACMP조환자뇌척액중Glu、Asp수평고우대조조[(3.76±1.52)μmol/L비(1.55±1.03)μmol/L;(0.73±0.44)μmol/L비(0.38±0.33)μmol/L,P균<0.01],차신경공능결손정도월중,Glu화Asp수평월고.결론 흥강성안기산삼여DEACMP병리과정,뇌척액중흥강성안기산수평승고,가능제시조기DEACMP적발생.
Objective To investigate the changes of excitatory amino acids (EAAs) of cerebrospinalfluid (CSF) in patients with delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Method The EAAs levels of CSF including glutamate (Glu) and aspartate (Asp) in 24 patients with DEACMP and 20 controls with migraine were measured by high performance liquid chromatography( HPLC ).Results Glu and Asp levels in patients with DEACMP were significantly higher than those of the controls [(3.76 ± 1.52) μmol/L vs ( 1.55 ± 1.03 ) μmol/L, (0.73 ± 0.44) μmol/L vs (0.38 ± 0.33 ) μmol/L, P all <0.01]. Glu and Asp levels in moderate and severe DEACMP patients were higher than those in mild DEACMP patients. Conclusion It suggests that EAAs participated in the pathogenesis of DEACMP. The Glu and Asp levels in CSF may be regarded as indicator of DEACMP.