CAJ | 학술논문

目的建立半衰期较长的18F-氟乙酸盐(FAC)的制备方法.方法基于Siemens公司的Explora FDG4合成模块,增加3个试剂位和2个电磁阀,改编运行程序,以"两锅法"结合Sep-Pak简易分离柱的使用,完成18F-FAC的自动化合成.对荷W256肝癌大鼠行18F-FAC PET/CT显像.结果该法合成时间为65 min,化学收率60%(时间校正),产品放化纯>98%.荷瘤大鼠PET显像示,30和120 min肿瘤标准摄取值(SUV)分别为1.37和1.20,肿瘤/前肢肌肉放射性比值分别为2.32和2.55.结论用改进的Explora FDG4合成模块可以成功制备放化纯较高的18F-FAC.18F-FAC是一种有潜在应用价值的肝癌显像剂.
목적 건립반쇠기교장적18F-불을산염(FAC)적제비방법.방법 기우Siemens공사적Explora FDG4합성모괴,증가3개시제위화2개전자벌,개편운행정서,이"량과법"결합Sep-Pak간역분리주적사용,완성18F-FAC적자동화합성.대하W256간암대서행18F-FAC PET/CT현상.결과 해법합성시간위65 min,화학수솔60%(시간교정),산품방화순>98%.하류대서PET현상시,30화120 min종류표준섭취치(SUV)분별위1.37화1.20,종류/전지기육방사성비치분별위2.32화2.55.결론 용개진적Explora FDG4합성모괴가이성공제비방화순교고적18F-FAC.18F-FAC시일충유잠재응용개치적간암현상제.
Objective PET/CT with 11C-acetate has a high sensitivity for detection of liver cancer and some cancers that arc poorly detected with 18F-fluorodeoxyglueose (FDG). However, the short half-life of 11C nuclide (11C = 20.4 min) limits the general availability of 11C-acetate. 18F-fluoroaeetate (FAC), an analog of acetate, has the advantage with a longer radioactive half-life (18F = 110 min). The aim of the study was to establish a method for preparing 18F-FAC. Methods In this study, a new automated synthesis of vF-FAC based on modified Siemens Explora FDG4 module was carried out by "two pots" reaction. The modified content of synthesis equipment included addition of 2 valves for liquid solution, 3 reagent position and new synthesis PC program. W256 liver tumor cells baring rats underwent 18F-FAC PET/CT imaging. Results The good separation and purity of final production were adopted via Sep-Pak cartridge extraction. The synthesis of 18F-FAC could be completed within 65 min, with about 60% (time calculated) of radio-chemical yield and more than 98% of radiochemicai purity. The standardized uptake value (SUV) of tumor in the rats was 1.37 and 1.20 at 30 and 120 min, the radioactivity ratios of tumor to muscle were 2.32 and 2.55, respectively. Conclusion Automated synthesis of 18F-FAC, a promising tracer for PET imaging of liver cancer, was developed successfully based upon modified Explora FDG4 module with good results.