CAJ | 학술논문

肺动脉高压的发病机制复杂,治疗方法局限,预后差.越来越多的研究表明炎症反应在肺动脉高压发病机制中起着重要的作用,已成为肺动脉高压发生、发展的重要机制之一.炎症机制包括各种细胞因子之间复杂的相互作用及其复杂的血管效应.本文综述了实验和临床研究的各种证据,总结炎症反应在各类型肺动脉高压中的作用,有望通过对该机制的研究探索新的治疗方法.
폐동맥고압적발병궤제복잡,치료방법국한,예후차.월래월다적연구표명염증반응재폐동맥고압발병궤제중기착중요적작용,이성위폐동맥고압발생、발전적중요궤제지일.염증궤제포괄각충세포인자지간복잡적상호작용급기복잡적혈관효응.본문종술료실험화림상연구적각충증거,총결염증반응재각류형폐동맥고압중적작용,유망통과대해궤제적연구탐색신적치료방법.
Pulmonary arterial hypertension(PAH)is a serious lung and heart disease with a poorly understood pathophysiology,limited therapeutic options,and a dismal prognosis.Accumulating evidence suggests that inflammation plays an important role in the pathogenesis of PAH.Inflammatory mechanism involves the complex interaction of cytokines and the following multiple vascular effects.This review summarizes the experimental and clinical evidence for inflammation in various types of PAH.The further investigation of inflammatory mechanism will provide a novel therapy for PAH.