中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
24期
27-29
,共3页
陈小烽%姜利佳%陈秀芳%麻叙良%叶琼%张理想%金良达
陳小烽%薑利佳%陳秀芳%痳敘良%葉瓊%張理想%金良達
진소봉%강리가%진수방%마서량%협경%장이상%금량체
食管肿瘤%基质金属蛋白酶2%半胱氨酸富集蛋白61
食管腫瘤%基質金屬蛋白酶2%半胱氨痠富集蛋白61
식관종류%기질금속단백매2%반광안산부집단백61
Esophageal neoplasms%Matrix metalloproteinase 2%C ysteine rich protein 61
目的 检测基质金属蛋白酶-2(MMP-2)、半胱氨酸富集蛋白61（Cyr61）及CD25在食管鳞癌中的表达并探讨其临床意义。方法 采用免疫组织化学法分别检测68例食管鳞癌患者肿瘤组织（食管癌组）、癌旁组织（癌旁组）和68例反流性食管炎患者病变组织（对照组）中的MMP-2、Cyr61及CD25，对检测结果进行统计分析。结果 食管癌组中MMP-2、Cyr61和CD25的阳性表达率分别为82.35％( 56/68)、73.53％ (50/68)和89.71％(61/68)，与癌旁组、对照组比较差异均有统计学意义(P＜0.05)；癌旁组与对照组比较差异无统计学意义(P＞0.05)；食管癌组织中MMP-2、Cyr61和CD25的阳性表达率在不同T分期、N分期和M分期中差异均有统计学意义(P＜0.05)，在不同的分化程度中差异则无统计学意义(P＞0.05)。结论 MMP-2、Cyr61及CD25在食管鳞癌中均有高表达，对其进行检测对了解食管鳞癌的发生、发展以及预后判断有一定指导意义。
目的 檢測基質金屬蛋白酶-2(MMP-2)、半胱氨痠富集蛋白61（Cyr61）及CD25在食管鱗癌中的錶達併探討其臨床意義。方法 採用免疫組織化學法分彆檢測68例食管鱗癌患者腫瘤組織（食管癌組）、癌徬組織（癌徬組）和68例反流性食管炎患者病變組織（對照組）中的MMP-2、Cyr61及CD25，對檢測結果進行統計分析。結果 食管癌組中MMP-2、Cyr61和CD25的暘性錶達率分彆為82.35％( 56/68)、73.53％ (50/68)和89.71％(61/68)，與癌徬組、對照組比較差異均有統計學意義(P＜0.05)；癌徬組與對照組比較差異無統計學意義(P＞0.05)；食管癌組織中MMP-2、Cyr61和CD25的暘性錶達率在不同T分期、N分期和M分期中差異均有統計學意義(P＜0.05)，在不同的分化程度中差異則無統計學意義(P＞0.05)。結論 MMP-2、Cyr61及CD25在食管鱗癌中均有高錶達，對其進行檢測對瞭解食管鱗癌的髮生、髮展以及預後判斷有一定指導意義。
목적 검측기질금속단백매-2(MMP-2)、반광안산부집단백61（Cyr61）급CD25재식관린암중적표체병탐토기림상의의。방법 채용면역조직화학법분별검측68례식관린암환자종류조직（식관암조）、암방조직（암방조）화68례반류성식관염환자병변조직（대조조）중적MMP-2、Cyr61급CD25，대검측결과진행통계분석。결과 식관암조중MMP-2、Cyr61화CD25적양성표체솔분별위82.35％( 56/68)、73.53％ (50/68)화89.71％(61/68)，여암방조、대조조비교차이균유통계학의의(P＜0.05)；암방조여대조조비교차이무통계학의의(P＞0.05)；식관암조직중MMP-2、Cyr61화CD25적양성표체솔재불동T분기、N분기화M분기중차이균유통계학의의(P＜0.05)，재불동적분화정도중차이칙무통계학의의(P＞0.05)。결론 MMP-2、Cyr61급CD25재식관린암중균유고표체，대기진행검측대료해식관린암적발생、발전이급예후판단유일정지도의의。
Objective To determine the expression of matrix metalloproteinase-2 (MMP-2),cysteine rich protein 61 (Cyr61) and CD25 in esophageal carcinoma and investigate their clinical significance.Method The expression of MMP-2, Cyr61 and CD25 in 68 cases of esophageal tumor tissues (esophageal carcinoma group ) and part-cancer( para-cancer group ) and 68 cases of reflux esophagitis (control group ) was detected by immunohistochemical method and the results were statistically analysed. Results The positive expression rates of MMP-2,Cyr61 and CD25 were 82.35％(56/68), 73.53％(50/68) and 89.71％(61/68)respectively in esophageal carcinoma group,there were significant differences compared with those in paracancer group and control group(P ＜ 0.05) ; while there was no significantdifference between para-cancer group and control group (P ＞ 0.05 ). The positive expression rates of MMP-2, Cyr61 and CD25 in esophageal carcinoma group in different T stage, N stage and M stage all had statisticall differences (P ＜ 0.05),while there was no significant difference in different degree of differentiation (P ＞ 0.05 ). Conclusion MMP-2,Cyr61 and CD25 is highly expressed in esophageal carcinoma,there is some significance for understanding the occurrence, development and prognosis of esophageal carcinoma.
