CAJ | 학술논문

目的研究异丙酚对肺缺血/再灌注损伤的保护作用.方法复制肺缺血再灌注损伤大鼠模型,将成年Wistar大鼠随机分为3组,A组为假手术组;B组为肺缺血-再灌注组,C组为异丙酚组,每组15只.用酶联免疫吸附(ELISA)法检测支气管肺泡灌洗液(BALF)中TNF-α、IL-6的含量.同时对各组动物血气和肺湿/干重比(W/D)进行检测.结果异丙酚能明显改善缺血再灌注动物的血氧分压,减少肺W/D值,降低BALF中TN-α、IL-6含量.结论异丙酚抑制肺缺血再灌注时炎性细胞因子的表达,从而减轻细胞因子介导的炎性损伤,具有肺保护作用.
목적 연구이병분대폐결혈/재관주손상적보호작용.방법 복제폐결혈재관주손상대서모형,장성년Wistar대서수궤분위3조,A조위가수술조;B조위폐결혈-재관주조,C조위이병분조,매조15지.용매련면역흡부(ELISA)법검측지기관폐포관세액(BALF)중TNF-α、IL-6적함량.동시대각조동물혈기화폐습/간중비(W/D)진행검측.결과 이병분능명현개선결혈재관주동물적혈양분압,감소폐W/D치,강저BALF중TN-α、IL-6함량.결론 이병분억제폐결혈재관주시염성세포인자적표체,종이감경세포인자개도적염성손상,구유폐보호작용.
Objective To study the protective effects of propofol against ischemia/reperfusion injury in rat lung. Methods Rat model of pulmonary ischemia/reperfusion injury was used in this study. Rats were randomly divided into three groups, including sham opera-tion group (group A), iachemia/reperfusion group (group B) and propofol group (group C), 15 rats in each group. The concentration of tumor necrosis factor -α and interleukin-6 in bronchoalveolar lavage fluid (BALF) were measured by enzyme linked immunosorbent assay (ELISA). Then blood gas analysis, lung wet/dry (W/D) weight ratio were detected in each group. Results Propofol could significantly improve PaO2, reduce the W/D value and the contents of TNF-α and IL-6 in BALF. Conclusion Propofol effectively suppressed the pro-duction and release of inflammatory cytokine, therefore it can protect the lung from isehemia/reperfusion injury.