CAJ | 학술논문

目的建立高胰岛素正常血糖葡萄糖钳夹平台及中国人胰岛素敏感性的正常参考值.方法采用DeFronzo建立的反馈数学模型原理在90名中国人健康受试者[男71例,女19例,年龄为(28.3±6.1)岁,体重指数为(20.9±1.5)kg/m2)]中进行高胰岛素正常血糖葡萄糖钳夹研究.结果在整个钳夹过程中,实测血糖值控制在其目标水平±10%以内,变异系数为3.8%±0.1%.稳态状态下测定的胰岛素敏感性参数葡萄糖代谢率(M值)属正态分布,均值为(7.78±2.30)mg·kg-1·min-1,下四分位数界点为6.286 mg·ks-1·min-1.M值在重复钳夹试验中的变异系数为9.4%±2.8%.结论正常血糖葡萄糖钳夹平台成功建立,并获得了中国人胰岛素敏感性参数M值的正常参考值.
목적 건립고이도소정상혈당포도당겸협평태급중국인이도소민감성적정상삼고치.방법 채용DeFronzo건립적반궤수학모형원리재90명중국인건강수시자[남71례,녀19례,년령위(28.3±6.1)세,체중지수위(20.9±1.5)kg/m2)]중진행고이도소정상혈당포도당겸협연구.결과 재정개겸협과정중,실측혈당치공제재기목표수평±10%이내,변이계수위3.8%±0.1%.은태상태하측정적이도소민감성삼수포도당대사솔(M치)속정태분포,균치위(7.78±2.30)mg·kg-1·min-1,하사분위수계점위6.286 mg·ks-1·min-1.M치재중복겸협시험중적변이계수위9.4%±2.8%.결론 정상혈당포도당겸협평태성공건립,병획득료중국인이도소민감성삼수M치적정상삼고치.
Objective To establish the technique of hyperinsulinemic euglycemic clamp and to study the reference value of insulin sensitivity index in healthy Chinese. Methods According to the feedback mathematical model developed by DeFronzo, the technique of hyperinsulinemic euglycemic clamp was used in 90 healthy Chi- nese [ male:female =71 = 19; age; (28. 3±6. 1) years; body mass index (20. 9±1.5) kg/m2 ] to study die glu-cose metabolized rate. Blood samples were obtained at timed intervals in the fasting state and during the clamp for the measurement of glucose, insulin and C peptide. Results During the clamp tests, the blood glucose levels were con-trolled within 10% of target value. The coefficient of variation of glucose levels was 3. 8% 0.1%. In the steady state, the insulin sensitivity index (glucose metabolized rate, M value ) was (7.78±2.30) mg· kg-1 min-1, which was distributed normally. The lowest quartile of M value was 6. 286 mg·kg -1 min-1'. The coefficient of variation of M value was 9.4%±2.8%. Conclusion The technique of hyperinsulinemic euglycemic clamp and the reference value of insulin sensitivity index in healthy Chinese are successfully established in our center.