中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2009年
1期
87-89
,共3页
陈璐%刘翠萍%徐宽枫%茅晓东%袁庆新%刘超
陳璐%劉翠萍%徐寬楓%茅曉東%袁慶新%劉超
진로%류취평%서관풍%모효동%원경신%류초
宫内发育迟缓%糖尿病,2型%胰岛β细胞功能%胰岛素敏感性
宮內髮育遲緩%糖尿病,2型%胰島β細胞功能%胰島素敏感性
궁내발육지완%당뇨병,2형%이도β세포공능%이도소민감성
Intrauterine growth retardation%Diabetes mellitus,type 2%Islet β-cell function%Insulin sensitivity
采用营养不良法建立官内发育迟缓(intrauterine growth retardation,IUGR)大鼠模型,发现IUGR大鼠胰腺发育受损、胰岛β细胞功能减退,随年龄增长逐渐出现糖耐量受损及胰岛素敏感性下降.
採用營養不良法建立官內髮育遲緩(intrauterine growth retardation,IUGR)大鼠模型,髮現IUGR大鼠胰腺髮育受損、胰島β細胞功能減退,隨年齡增長逐漸齣現糖耐量受損及胰島素敏感性下降.
채용영양불량법건립관내발육지완(intrauterine growth retardation,IUGR)대서모형,발현IUGR대서이선발육수손、이도β세포공능감퇴,수년령증장축점출현당내량수손급이도소민감성하강.
The intrauterine growth retardation (IUGR) model was established by maternal nutrition restriction during mid- to late-gestation. IUGR rats had both impaired pancreatic development and islet β-cell dysfunction. As the animals grew, the rats gradually showed impaired glucose tolerance and decreased insulin sensitivity.
