CAJ | 학술논문

目的:建立复方丹参多元释药双层片的体外释放度测定方法,并考察其体外释药特性和释药影响因素.方法:以丹酚酸B和人参皂苷Rg_1为指标,建立舣层片体外释放度的测定方法,并分别考察其速释层和缓释层的释放度影响因素以及体外释药行为.结果:双层片速释层具有明显的速释效果;缓释层的释药行为以Ritger-Peppas方程拟合效果最好;人工胃液对双层片中人参皂苷Rg_1的释放影响作用显著,而对丹酚酸B的释放影响不显著.结论:复方丹参多元释药双层片在体外具有良好的速释和缓释特征,达到了临床运用的要求效果.
목적:건립복방단삼다원석약쌍층편적체외석방도측정방법,병고찰기체외석약특성화석약영향인소.방법:이단분산B화인삼조감Rg_1위지표,건립의층편체외석방도적측정방법,병분별고찰기속석층화완석층적석방도영향인소이급체외석약행위.결과:쌍층편속석층구유명현적속석효과;완석층적석약행위이Ritger-Peppas방정의합효과최호;인공위액대쌍층편중인삼조감Rg_1적석방영향작용현저,이대단분산B적석방영향불현저.결론:복방단삼다원석약쌍층편재체외구유량호적속석화완석특정,체도료림상운용적요구효과.
AIM: To establish the drug release method of Compound Salvia Multi-component released Doublelayer Tablet and investigate its in vitro drug release behavior and the influencing factors of the drug release rate.METHODS: The method of evaluating in vitro release rate of double-layer tablet was established with salvianolic acid B and gindenoside Rg_1 as index,The influencing factors of the release of rapid release layer and sustained release layer of double-layer tablet and their in vitro drug release behavior were studied.RESULTS: The rapid release layer showed the quick releasing effect; The drug release curve of sustained release layer accorded with Ritger-Peppas equation; artificial gastric juice had significant effect on the release curve of gindenoside Rg_1 which in double-layer tablets,but had no significant effect on the release curve of salvianolic acid B.CONCLUSION: The evaluation of in vitro release rate of Compound Salvia Multi-component released Double-layer Tablet shows good properties of fast and sustained release and clinic application is achieved.