CAJ | 학술논문

综述了近年来国内外有关异烟酸合成方法的最新研究进展和成果.重点介绍了以聚4-吡啶乙烯、4-羟甲基吡啶、4-醛基吡啶和4-甲基吡啶为原料的化学氧化法,其中,以4-甲基吡啶为原料、空气/氧气为氧化剂的方法具有原料来源广泛、价格便宜、氧化剂清洁且廉价易得等优点,势必成为未来研究的热点.
종술료근년래국내외유관이연산합성방법적최신연구진전화성과.중점개소료이취4-필정을희、4-간갑기필정、4-철기필정화4-갑기필정위원료적화학양화법,기중,이4-갑기필정위원료、공기/양기위양화제적방법구유원료래원엄범、개격편의、양화제청길차렴개역득등우점,세필성위미래연구적열점.
Research progress in preparation of isonicotinic acid was reviewed in this paper.A comprehensive introduction was made on the chemical oxidation of poly(4-vinylpyridine),4-pyridinemethanol,4-aldehydepyridine,4-methylpyridine to synthesize isonicotinic acid.Further investigations will be focused on the oxidation of 4-methylpyridine by air/O_2,thanks to the advantages related with abundance of material supply,clean process as well as low price.