国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
14期
1048-1051
,共4页
肖祖克%吴西雅%周洪%郭玲玲
肖祖剋%吳西雅%週洪%郭玲玲
초조극%오서아%주홍%곽령령
隐源性机化性肺炎%胸部影像学%病理%诊断
隱源性機化性肺炎%胸部影像學%病理%診斷
은원성궤화성폐염%흉부영상학%병리%진단
Cryptogenie organizing pneumonia%Chest imaging%Pathology%Diagnosis
目的 回顾性分析14例经肺活检确诊的隐源性机化性肺炎(COP)的临床资料及随访情况,总结COP的临床、影像、病理学、转归和预后的特点.方法 回顾性分析2003年1月至2010年12月期间经肺活检证实的14例COP患者的临床表现、实验室资料、影像学表现、组织病理学特点、治疗和转归.结果 14例COP患者的男女比例相当,主要症状为咳嗽(100.0％)、呼吸困难(78.6％)、发热(85.7％)、乏力(78.6％)等.8例(57.1％)体检肺部有湿啰音.常规实验室检查结果异常有:血沉增快(71.4％)、C反应蛋白升高(64.3％)和贫血5例(35.7％).胸部CT示:病变双侧分布10例(71.4％),多发10例(71.4％),实变5例(35.7％),斑片状影8例(57.1％),条索状或毛玻璃影改变各2例,肿块状影1例,伴支气管充气症6例(42.9％).经糖皮质激素治疗,11例治愈,2例复发,再次治疗后治愈,1例随访中病情变化诊断为真菌感染.结论 本组COP患者临床表现缺乏特异性,胸部影像学以双侧、多发、实变和斑片状影为主.一般预后良好,糖皮质激素治疗有效.经支气管镜或经皮肺穿刺肺活检是诊断COP的主要手段.
目的 迴顧性分析14例經肺活檢確診的隱源性機化性肺炎(COP)的臨床資料及隨訪情況,總結COP的臨床、影像、病理學、轉歸和預後的特點.方法 迴顧性分析2003年1月至2010年12月期間經肺活檢證實的14例COP患者的臨床錶現、實驗室資料、影像學錶現、組織病理學特點、治療和轉歸.結果 14例COP患者的男女比例相噹,主要癥狀為咳嗽(100.0％)、呼吸睏難(78.6％)、髮熱(85.7％)、乏力(78.6％)等.8例(57.1％)體檢肺部有濕啰音.常規實驗室檢查結果異常有:血沉增快(71.4％)、C反應蛋白升高(64.3％)和貧血5例(35.7％).胸部CT示:病變雙側分佈10例(71.4％),多髮10例(71.4％),實變5例(35.7％),斑片狀影8例(57.1％),條索狀或毛玻璃影改變各2例,腫塊狀影1例,伴支氣管充氣癥6例(42.9％).經糖皮質激素治療,11例治愈,2例複髮,再次治療後治愈,1例隨訪中病情變化診斷為真菌感染.結論 本組COP患者臨床錶現缺乏特異性,胸部影像學以雙側、多髮、實變和斑片狀影為主.一般預後良好,糖皮質激素治療有效.經支氣管鏡或經皮肺穿刺肺活檢是診斷COP的主要手段.
목적 회고성분석14례경폐활검학진적은원성궤화성폐염(COP)적림상자료급수방정황,총결COP적림상、영상、병이학、전귀화예후적특점.방법 회고성분석2003년1월지2010년12월기간경폐활검증실적14례COP환자적림상표현、실험실자료、영상학표현、조직병이학특점、치료화전귀.결과 14례COP환자적남녀비례상당,주요증상위해수(100.0％)、호흡곤난(78.6％)、발열(85.7％)、핍력(78.6％)등.8례(57.1％)체검폐부유습라음.상규실험실검사결과이상유:혈침증쾌(71.4％)、C반응단백승고(64.3％)화빈혈5례(35.7％).흉부CT시:병변쌍측분포10례(71.4％),다발10례(71.4％),실변5례(35.7％),반편상영8례(57.1％),조색상혹모파리영개변각2례,종괴상영1례,반지기관충기증6례(42.9％).경당피질격소치료,11례치유,2례복발,재차치료후치유,1례수방중병정변화진단위진균감염.결론 본조COP환자림상표현결핍특이성,흉부영상학이쌍측、다발、실변화반편상영위주.일반예후량호,당피질격소치료유효.경지기관경혹경피폐천자폐활검시진단COP적주요수단.
Objective To analyze the clinical data of 14 cases of biopsy-proven crytogenic organizing penumonia(COP),so as to summarize the clinical,radiological,pathological,diagnostic and prognostic features.Methods The clinical-pathological characteristics,experimental data,radiological features,treatment and survival of 14 patients with COP were retrospectively researched,whom were confirmed by lung biopsy in Jiangxi Provincial People's Hospital from January 2003 to December 2010.Results The number of male or female was equivalent,the most common symptoms were cough (100.0％),dyspnea (78.6％),fever (85.7％),hypodynamia (78.6％),moist rales (57.1％).Blood tests showed elevated erythrocyte sedimentation rate (71.4％),elevated C-reactive protein (64.3％) and anemia (35.7％).Chest computed tomography displayed bilateral distribution ( 71.4％),consolidation (35.7％),patchy infiltrates (57.1％ ),ground-glass opacity ( 14.3 ％ ),airspace consolidation (42.9％ ),mass (14.3％).All the patients were treated by corticosteroid.11 cases were cured,Two cases were relapsed and then were recovered after corticosteroid therapy again.Fungus infection was diagnosed in one case in the follow-up.Conclusions The symptoms of COP are no-specific.Corticosteroid is the first choice for COP therapy and the prognosis of COP is well.
