中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
16期
2179-2180
,共2页
子宫内膜异位症%白细胞介素6%肿瘤坏死因子-α
子宮內膜異位癥%白細胞介素6%腫瘤壞死因子-α
자궁내막이위증%백세포개소6%종류배사인자-α
Endometriosis%Interleukin-6%Tumor necrosis factor-α
目的 通过检测子宫内膜异位症(EMS)患者腹腔液和血清白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,探讨其在EMS发病机制中的作用. 方法 采用酶联免疫吸附双抗体夹心法(ELISA)检测60例EMS患者(Ⅰ、Ⅱ期34例,Ⅲ、Ⅳ期26例)及30例对照组(同期非EMS患者)腹腔液和血清IL-6、TNF-α水平. 结果 EMS患者腹腔液和血清IL-6、TNF-α水平明显高于对照组(P＜0.01),且Ⅲ、Ⅳ期EMS患者腹腔液及血清IL-6、TNF-α水平明显高于Ⅰ、Ⅱ期(P＜0.01). 结论 EMS患者腹腔液和血清IL-6、TNF-α在EMS的发生、发展中均起着重要的作用.
目的 通過檢測子宮內膜異位癥(EMS)患者腹腔液和血清白細胞介素6(IL-6)、腫瘤壞死因子-α(TNF-α)水平,探討其在EMS髮病機製中的作用. 方法 採用酶聯免疫吸附雙抗體夾心法(ELISA)檢測60例EMS患者(Ⅰ、Ⅱ期34例,Ⅲ、Ⅳ期26例)及30例對照組(同期非EMS患者)腹腔液和血清IL-6、TNF-α水平. 結果 EMS患者腹腔液和血清IL-6、TNF-α水平明顯高于對照組(P＜0.01),且Ⅲ、Ⅳ期EMS患者腹腔液及血清IL-6、TNF-α水平明顯高于Ⅰ、Ⅱ期(P＜0.01). 結論 EMS患者腹腔液和血清IL-6、TNF-α在EMS的髮生、髮展中均起著重要的作用.
목적 통과검측자궁내막이위증(EMS)환자복강액화혈청백세포개소6(IL-6)、종류배사인자-α(TNF-α)수평,탐토기재EMS발병궤제중적작용. 방법 채용매련면역흡부쌍항체협심법(ELISA)검측60례EMS환자(Ⅰ、Ⅱ기34례,Ⅲ、Ⅳ기26례)급30례대조조(동기비EMS환자)복강액화혈청IL-6、TNF-α수평. 결과 EMS환자복강액화혈청IL-6、TNF-α수평명현고우대조조(P＜0.01),차Ⅲ、Ⅳ기EMS환자복강액급혈청IL-6、TNF-α수평명현고우Ⅰ、Ⅱ기(P＜0.01). 결론 EMS환자복강액화혈청IL-6、TNF-α재EMS적발생、발전중균기착중요적작용.
Objective To study the levels of interleukin-6(IL-6)and tumor necrosis factor-alfa(TNF- α)in serum and peritoneal fluid of women with endometriosis,to explore their roles in pathogenesis of endometriosis. Methods IL-6 and TNF-α levels in peritoneal fluid and serum of 60 patients with endometriosis(34 cases in Ⅰ ～ Ⅱ stage,26 cases in Ⅲ ～ Ⅳ stage)and 30 control cases(not EMS patients)were detected by enzyme linked immunosorbent assay(ELISA). Results Peritoneal fluid and serum levels of IL-6 and TNF-α in EMS group were significantly higher than that in control group(P＜0.01),and peritoneal fluid and serum levels of IL-6 and TNF-α in Ⅲ ～Ⅳ stage was siguificantly higher than that in Ⅰ ～ Ⅱ stage(P＜0.01). Conclusion IL-6 and TNF-α in peritoneal fluid and serum played an important role in pathogenesis of endometriosis.
