CAJ | 학술논문

目的回顾性分析适形调强放疗(IMRT)对鼻咽肿瘤退缩模式的影响.方法选取2001年4月至2007年12月间接受单纯放疗初治鼻咽癌患者,其中,IMRT 196例,常规放疗76例.IMRT组照射总疗程平均为6周,常规放疗组总疗程平均为7周.结果放疗结束时,IMRT组的鼻咽肿瘤和颈部淋巴结残留率分别为36.7％和44.2％,高于常规放疗组的21.1％和26.6％(x2=6.15和3.99,P＜0.05).放疗后3个月,IMRT组有6.1％残留,常规放疗组有9.2％残留,两组差异无统计学意义.IMRT组残留病灶在放疗后4～9个月时完全消退.结论采用IMRT治疗初治鼻咽癌,肿瘤的退缩模式与常规放疗不同.IMRT结束时,肿瘤残留率较高,但只要靶区剂量充足,不宜盲目追加剂量.
목적 회고성분석괄형조강방료(IMRT)대비인종류퇴축모식적영향.방법 선취2001년4월지2007년12월간접수단순방료초치비인암환자,기중,IMRT 196례,상규방료76례.IMRT조조사총료정평균위6주,상규방료조총료정평균위7주.결과 방료결속시,IMRT조적비인종류화경부림파결잔류솔분별위36.7％화44.2％,고우상규방료조적21.1％화26.6％(x2=6.15화3.99,P＜0.05).방료후3개월,IMRT조유6.1％잔류,상규방료조유9.2％잔류,량조차이무통계학의의.IMRT조잔류병조재방료후4～9개월시완전소퇴.결론 채용IMRT치료초치비인암,종류적퇴축모식여상규방료불동.IMRT결속시,종류잔류솔교고,단지요파구제량충족,불의맹목추가제량.
Objective To retrospectively analyze the influence of intensity-modulated radiotherapy (IMRT) on tumor regression in primary nasopharyngeal carcinoma (NPC).Methods 272 patients with NPC received radical radiotherapy alone,196 by IMRT with a total treatment time of 6 weeks,and 76 by bilateral field conventional radiotherapy (CRT) with the total treatment timc of 7 weeks.Results By the end of radiotherapy,the primary tumor and neck lymph node residual rates of the IMRT group were 36.7％ and 44.2％,respectively,both significantly higher than those of the GRT group (21.1％ and 26.6％,x2 =6.15,3.99,P ＜ 0.05).Three months after the radiotherapy,residual lesions were observed at the nasopharynx or neck lymph nodes in 12 of the IMRT group,with a residual rate of 6.1％,not significantly different from that of the CRT group (9.2％,7/76).The 12 residual lesions of the IMRT group all vanished completely 4 -9 months after the radiotherapy.Conclusions There is an obvious difference in regressive mode between IMRT and CRT technique in NPC treatment.At the end of IMRT,the tumor residual rate is slightly increased.However,the delivered dose of gross tumor volume (GTV) is sufficient,and the boost dose should not be delivered indiscreetly.