中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2009年
27期
1930-1933
,共4页
陈龙%陈临炜%陈辉%郭晓山%徐华梓%张国佑%祁旦巳
陳龍%陳臨煒%陳輝%郭曉山%徐華梓%張國祐%祁旦巳
진룡%진림위%진휘%곽효산%서화재%장국우%기단사
骨质疏松%维甲酸%生物力学
骨質疏鬆%維甲痠%生物力學
골질소송%유갑산%생물역학
Osteoporosis%Retinoin%Biomechanics
目的 探讨阿仑膦酸钠(福善美)强骨胶囊及二者合用对维甲酸致骨质疏松性大鼠骨折的影响.方法 通过维甲酸80mg·kg-1·d-1灌胃15 d制造实验性雌性SD大鼠骨质疏松模型65只,5只经确认造膜成功后,剩余60只随机分成4组(每组15只).用咬骨钳造成右侧股骨骨折,用克氏针髓内固定,术后第2天分别给予灌胃对照组生理盐水8 ml·kg-1·W-1,福善美40 mg·kg-1·W-1,强骨胶囊90 mg·kg-1·d-1及二者合用,并分别于2、4、6周处死并行X线检查,取右侧股骨标本行组织学检查,另取左侧股骨给予生物力学测试以了解福善美和强骨胶囊对实验性骨质疏松性大鼠的生物力学影响.结果 4周时二者单用或合用均能改善骨质疏松大鼠股骨的生物力学性能(25.2±4.8,23.7±1.2,26.7±2.8,26.5±3.8,P<0.05),合用不好于单用;4周时福善美X线骨痂测量较大(P<0.05);抑制破骨细胞明显,骨痂生长塑形稍慢.强骨胶囊x线骨痂测量较小(P<0.05);可见加速编织骨向板状骨转换.结论 福善美和强骨胶囊及二者合用均能增加维甲酸所致的骨质疏松性大鼠股骨的生物力学性能.强骨胶囊能促进维甲酸所致的骨质疏松性大鼠股骨骨折愈合.
目的 探討阿崙膦痠鈉(福善美)彊骨膠囊及二者閤用對維甲痠緻骨質疏鬆性大鼠骨摺的影響.方法 通過維甲痠80mg·kg-1·d-1灌胃15 d製造實驗性雌性SD大鼠骨質疏鬆模型65隻,5隻經確認造膜成功後,剩餘60隻隨機分成4組(每組15隻).用咬骨鉗造成右側股骨骨摺,用剋氏針髓內固定,術後第2天分彆給予灌胃對照組生理鹽水8 ml·kg-1·W-1,福善美40 mg·kg-1·W-1,彊骨膠囊90 mg·kg-1·d-1及二者閤用,併分彆于2、4、6週處死併行X線檢查,取右側股骨標本行組織學檢查,另取左側股骨給予生物力學測試以瞭解福善美和彊骨膠囊對實驗性骨質疏鬆性大鼠的生物力學影響.結果 4週時二者單用或閤用均能改善骨質疏鬆大鼠股骨的生物力學性能(25.2±4.8,23.7±1.2,26.7±2.8,26.5±3.8,P<0.05),閤用不好于單用;4週時福善美X線骨痂測量較大(P<0.05);抑製破骨細胞明顯,骨痂生長塑形稍慢.彊骨膠囊x線骨痂測量較小(P<0.05);可見加速編織骨嚮闆狀骨轉換.結論 福善美和彊骨膠囊及二者閤用均能增加維甲痠所緻的骨質疏鬆性大鼠股骨的生物力學性能.彊骨膠囊能促進維甲痠所緻的骨質疏鬆性大鼠股骨骨摺愈閤.
목적 탐토아륜련산납(복선미)강골효낭급이자합용대유갑산치골질소송성대서골절적영향.방법 통과유갑산80mg·kg-1·d-1관위15 d제조실험성자성SD대서골질소송모형65지,5지경학인조막성공후,잉여60지수궤분성4조(매조15지).용교골겸조성우측고골골절,용극씨침수내고정,술후제2천분별급여관위대조조생리염수8 ml·kg-1·W-1,복선미40 mg·kg-1·W-1,강골효낭90 mg·kg-1·d-1급이자합용,병분별우2、4、6주처사병행X선검사,취우측고골표본행조직학검사,령취좌측고골급여생물역학측시이료해복선미화강골효낭대실험성골질소송성대서적생물역학영향.결과 4주시이자단용혹합용균능개선골질소송대서고골적생물역학성능(25.2±4.8,23.7±1.2,26.7±2.8,26.5±3.8,P<0.05),합용불호우단용;4주시복선미X선골가측량교대(P<0.05);억제파골세포명현,골가생장소형초만.강골효낭x선골가측량교소(P<0.05);가견가속편직골향판상골전환.결론 복선미화강골효낭급이자합용균능증가유갑산소치적골질소송성대서고골적생물역학성능.강골효낭능촉진유갑산소치적골질소송성대서고골골절유합.
Objective To study the effectiveness of retinoic acid on induction of osteoporotic rats
treated by either alendronate or Qianggu capsules and co-administration. Methods Sixty-five female SD rats were treated with retinoic acid 80 mg·kg-1·d-1by gastric lavage for 15 days. Then 5 rats were confirmed cases of esteoporosis and the remaining 60 were randomly divided into 4 groups 15 each: (1) control group with NS 8 ml·kg-1·w-1; (2) alendronate group with alendronate 40 mg·kg-1·w-1; (3) qianggu group with Qianggu capsules 90 mg·kg-1·d-1; (4) co-medicated group with alendronate 40 mg·kg-1w-1 and Qianggu capsules 90 mg·kg-1d-1. Five rats in each group were sacrificed at week 2, 4 and 6 respectively to carry out the biomechanic tests, histopsthologic examination and bony callus volume calculation.Results Biomechanical properties of femur changed significantly after the treatment by alendronate or Qianggu capsules and co-medication as compared with that of NS after 4 weeks (P<0.05);the bony callus were larger when treated by alendronate (P<0.05) and smaller by Qianggu capsules (P> 0.05); the bone trabecula formed and rebuilding were slower by alendronate and quicker by Qianggu capsules. Conclusion Alendronate or Qianggu capsules and co-medication can improve biomechanieal properties of femur by retinoic acid on induction of esteoporotic rats. Qianggu capsules can improve bone union.
