CAJ | 학술논문

目的探讨P27kipl和Ki67的表达与结肠癌的发生、发展的关系.方法采用免疫组织化学方法检测64例结肠癌组织和癌旁正常组织中P27 kipl和Ki67的表达.结果 P27kipl 和Ki67在结肠癌组织中的阳性表达率分别为23.44%和46.88%,它们在癌旁E--常组织中的阳性表达率分别为87.50%和3.13%.P27kipl和Ki67在结肠癌中的表达与年龄、性别无关(P＞0.05),与不同分化程度、Dukes分级和淋巴结是否转移有关(P＜0.05).且P27kipl与Ki67的表达呈负相关(P＜0.05).结论 P27kipl的表达下调和Ki67的表达上调在结肠癌的发生、发展和转移过程中起着重要的作用.
목적 탐토P27kipl화Ki67적표체여결장암적발생、발전적관계.방법 채용면역조직화학방법검측64례결장암조직화암방정상조직중P27 kipl화Ki67적표체.결과 P27kipl 화Ki67재결장암조직중적양성표체솔분별위23.44%화46.88%,타문재암방E--상조직중적양성표체솔분별위87.50%화3.13%.P27kipl화Ki67재결장암중적표체여년령、성별무관(P＞0.05),여불동분화정도、Dukes분급화림파결시부전이유관(P＜0.05).차P27kipl여Ki67적표체정부상관(P＜0.05).결론 P27kipl적표체하조화Ki67적표체상조재결장암적발생、발전화전이과정중기착중요적작용.
Objective To explore the expressions of P27kipl and Ki67 were correlated with genesis and progression of human colonic cancer.Methods Expressions of F27kipl and Ki67 at protein level were determined bv using immunohistochenlistry technique in 64 cases of tissue and side tissue of colonic cancer.Results The D0sitive expression rates of P27 kipl and Ki67 in colonic cancer issue were 23.44%and 46.88%,and side issue were 87.50%and 3.13%.The expressions of P27kipl and Ki67 in colonic cancer were not related to age or sex(P＞0.05),and related to differentiation grade,Dukes stage and lymph node metastasis(P＜0.05).A significant negative correlation was observed between the expression of P27 kipl and Ki67(P＜0.05).Conclusion The down-regulation of P27kipl and up-regulation of Ki67 play an important role in the genesis.progression and metastasis of colonic cancer.