蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2009年
7期
588-589
,共2页
心肌梗死%白细胞计数%C反应蛋白%心肌肌钙蛋白%肌红蛋白
心肌梗死%白細胞計數%C反應蛋白%心肌肌鈣蛋白%肌紅蛋白
심기경사%백세포계수%C반응단백%심기기개단백%기홍단백
myocardial infarction%leukocyte count%C reactive protein%cardiac troponin I%myoglobin
目的:探讨WBC计数在急性心肌梗死(acute myocardial infarction,AMI)中的早期诊断价值.方法:选择AMI早期就诊患者47例(胸痛时间＜2 h,肌红蛋白阴性,无其他炎症相关疾病),分别于入院即刻和胸痛发生后4～8 h、12～24 h采集静脉血,分别检测WBC、C反应蛋白(CRP)、心肌肌钙蛋白I(cTNI)与肌红蛋白(Mb).并于出院后3～12个月,跟踪监测WBC 3次,取其平均值作为自身对照.同时检测健康人群WBC和CRP作正常对照.结果:AMI胸痛发作2 h内,在Mb阴性时,WBC即开始升高(9.12±2.18)×109/L,显著高于自身对照(6.49±1.09)×109/L和正常对照组(5.97±1.24)×109/L(P＜0.01).但中性粒细胞与自身对照相比差异无统计学意义(P＞0.05);CRP与对照组相比差异无统计学意义(P＞0.05).在Mb和cTNI阳性后WBC和CRP显著升高(P＜0.01),在12～24 h达峰值,分别为(12.46±5.28)×109/L和(50.9±21.3)×109/L,同时中性粒细胞也显著升高(P＜0.01).结论:AMI发作早期,Mb和cTNI阴性时,WBC即显著升高,因此WBC计数对早期AMI有一定的诊断价值.
目的:探討WBC計數在急性心肌梗死(acute myocardial infarction,AMI)中的早期診斷價值.方法:選擇AMI早期就診患者47例(胸痛時間＜2 h,肌紅蛋白陰性,無其他炎癥相關疾病),分彆于入院即刻和胸痛髮生後4～8 h、12～24 h採集靜脈血,分彆檢測WBC、C反應蛋白(CRP)、心肌肌鈣蛋白I(cTNI)與肌紅蛋白(Mb).併于齣院後3～12箇月,跟蹤鑑測WBC 3次,取其平均值作為自身對照.同時檢測健康人群WBC和CRP作正常對照.結果:AMI胸痛髮作2 h內,在Mb陰性時,WBC即開始升高(9.12±2.18)×109/L,顯著高于自身對照(6.49±1.09)×109/L和正常對照組(5.97±1.24)×109/L(P＜0.01).但中性粒細胞與自身對照相比差異無統計學意義(P＞0.05);CRP與對照組相比差異無統計學意義(P＞0.05).在Mb和cTNI暘性後WBC和CRP顯著升高(P＜0.01),在12～24 h達峰值,分彆為(12.46±5.28)×109/L和(50.9±21.3)×109/L,同時中性粒細胞也顯著升高(P＜0.01).結論:AMI髮作早期,Mb和cTNI陰性時,WBC即顯著升高,因此WBC計數對早期AMI有一定的診斷價值.
목적:탐토WBC계수재급성심기경사(acute myocardial infarction,AMI)중적조기진단개치.방법:선택AMI조기취진환자47례(흉통시간＜2 h,기홍단백음성,무기타염증상관질병),분별우입원즉각화흉통발생후4～8 h、12～24 h채집정맥혈,분별검측WBC、C반응단백(CRP)、심기기개단백I(cTNI)여기홍단백(Mb).병우출원후3～12개월,근종감측WBC 3차,취기평균치작위자신대조.동시검측건강인군WBC화CRP작정상대조.결과:AMI흉통발작2 h내,재Mb음성시,WBC즉개시승고(9.12±2.18)×109/L,현저고우자신대조(6.49±1.09)×109/L화정상대조조(5.97±1.24)×109/L(P＜0.01).단중성립세포여자신대조상비차이무통계학의의(P＞0.05);CRP여대조조상비차이무통계학의의(P＞0.05).재Mb화cTNI양성후WBC화CRP현저승고(P＜0.01),재12～24 h체봉치,분별위(12.46±5.28)×109/L화(50.9±21.3)×109/L,동시중성립세포야현저승고(P＜0.01).결론:AMI발작조기,Mb화cTNI음성시,WBC즉현저승고,인차WBC계수대조기AMI유일정적진단개치.
Objective:To investigate the diagnostic value of changes of leukocyte count in patients with acute myocardial infarction(AMI).Methods:A total of 47 patients with AMI were selected according to the following standards:the chest pain lasted for no more than 2 hours,the myoglobin(Mb) was negative,and no one had diseases related to inflammation.The blood samples were obtained respectively at the time of onset,4-8 h and 12-24 h after the chest pain.And the leukocyte-reactive protein,cardiac troponin I(cTNI)and Mb were detected.All the patients were followed up for 3-12 months.During this period,their WBC was examined for three times,and the mean value was compared with that of the autoleukocyte controls as well as that of the normal control.Results:Within 2 hours of the onset of chest pain and with the Mb still negative,the leukocyte count in the AMI patients began to rise (9.12±2.18)×109/L,which was higher than that of the autoleukocyte controls(6.49±1.09)×109/L and the normal control(5.97±1.24)×109/L(P＜0.01).But neutrophil percentage presented no significant difference between AMI patients and the autoleukocyte controls at the time of onset(P＞0.05).There was no significant difference in C reactive protein(CRP)levels between AMI patients and the normal control at the time of onset(P＞0.05).The levels of WBC and CRP in AMI patients increased significantly after Mb and cTNI became positive(P＜0.01),and reached their peak at 12-24 hours after the onset of chest pain.At the same time neutrophil percentage increased significantly,too(P＜0.01).Conclusions:The white cell count begins to rise significantly at the onset of acute myocardial infarction when the Mb and cTNI are still negative.So the increase of leukocyte count is one of the early symptoms of AMI.
