中国医学科学院学报
中國醫學科學院學報
중국의학과학원학보
ACTA ACADEMIAE MEDICINAE SINICAE
2010年
2期
157-161
,共5页
黄蓉%肖毅%钟旭%黎明%黄席珍
黃蓉%肖毅%鐘旭%黎明%黃席珍
황용%초의%종욱%려명%황석진
阻塞性睡眠呼吸暂停低通气综合征%高血压%瘦素
阻塞性睡眠呼吸暫停低通氣綜閤徵%高血壓%瘦素
조새성수면호흡잠정저통기종합정%고혈압%수소
obstructive sleep apnea hypopnea syndrome%hypertension%leptin
目的 研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与高血压及瘦素的关系,初步探讨睡眠呼吸紊乱及瘦素在OSAHS并发高血压发病中的作用.方法 测定60例OSAHS及40例年龄、体质指数(BMI)相匹配对照组睡前及醒后血压(BP)、醒后心率(HR),血清瘦素(LEp)水平,同时测定BMI、颈围(NC)、腰臀比(WHR)、血清空腹血糖(FBG)、三酰甘油(TG)、胆固醇(Chol)、空腹真胰岛素(TI)水平.对比两组睡前、醒后BP变化;分析睡眠呼吸紊乱参数及瘦素与高血压的相关关系.结果 OSAHS组与对照组睡前血压差异无显著性(P>0.05),但醒后血压尤其是舒张压(89.75±2.04)mmHg显著高于对照组(81.63±1.91)mmHg并独立于年龄和肥胖(P<0.01);OSAHS组DBP与瘦素、呼吸暂停低通气指数(AHI)呈正相关(r=0.282,P<0.05;r=0.318,P<0.01);BMI(P=0.029)、醒后HR(P=0.030)及瘦素(P=0.049)可能是高血压发生的独立相关因素.结论 睡眠呼吸紊乱可能对醒后血压,尤其是醒后舒张压产生独立的效应;而BMI、醒后HR和瘦素可能是高血压的独立相关因素.
目的 研究阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)與高血壓及瘦素的關繫,初步探討睡眠呼吸紊亂及瘦素在OSAHS併髮高血壓髮病中的作用.方法 測定60例OSAHS及40例年齡、體質指數(BMI)相匹配對照組睡前及醒後血壓(BP)、醒後心率(HR),血清瘦素(LEp)水平,同時測定BMI、頸圍(NC)、腰臀比(WHR)、血清空腹血糖(FBG)、三酰甘油(TG)、膽固醇(Chol)、空腹真胰島素(TI)水平.對比兩組睡前、醒後BP變化;分析睡眠呼吸紊亂參數及瘦素與高血壓的相關關繫.結果 OSAHS組與對照組睡前血壓差異無顯著性(P>0.05),但醒後血壓尤其是舒張壓(89.75±2.04)mmHg顯著高于對照組(81.63±1.91)mmHg併獨立于年齡和肥胖(P<0.01);OSAHS組DBP與瘦素、呼吸暫停低通氣指數(AHI)呈正相關(r=0.282,P<0.05;r=0.318,P<0.01);BMI(P=0.029)、醒後HR(P=0.030)及瘦素(P=0.049)可能是高血壓髮生的獨立相關因素.結論 睡眠呼吸紊亂可能對醒後血壓,尤其是醒後舒張壓產生獨立的效應;而BMI、醒後HR和瘦素可能是高血壓的獨立相關因素.
목적 연구조새성수면호흡잠정저통기종합정(OSAHS)여고혈압급수소적관계,초보탐토수면호흡문란급수소재OSAHS병발고혈압발병중적작용.방법 측정60례OSAHS급40례년령、체질지수(BMI)상필배대조조수전급성후혈압(BP)、성후심솔(HR),혈청수소(LEp)수평,동시측정BMI、경위(NC)、요둔비(WHR)、혈청공복혈당(FBG)、삼선감유(TG)、담고순(Chol)、공복진이도소(TI)수평.대비량조수전、성후BP변화;분석수면호흡문란삼수급수소여고혈압적상관관계.결과 OSAHS조여대조조수전혈압차이무현저성(P>0.05),단성후혈압우기시서장압(89.75±2.04)mmHg현저고우대조조(81.63±1.91)mmHg병독립우년령화비반(P<0.01);OSAHS조DBP여수소、호흡잠정저통기지수(AHI)정정상관(r=0.282,P<0.05;r=0.318,P<0.01);BMI(P=0.029)、성후HR(P=0.030)급수소(P=0.049)가능시고혈압발생적독립상관인소.결론 수면호흡문란가능대성후혈압,우기시성후서장압산생독립적효응;이BMI、성후HR화수소가능시고혈압적독립상관인소.
Objective To explore the roles of hypertension and serum leptin in obstructive sleep ap-nea hypopnea syndrome (OSAHS). Methods Totally 60 patients with OSAHS (OSAHS group) and 40 age-and body mass index ( BMI) -matched non-OSAHS individuals ( non-OSAHS group) were enrolled in this study. The neck circumference (NC), waist/hip rate (WHR) , systolic blood pressure (SBP), diastolic blood pressure (DBP) , leptin, fasting blood glucose (FBG), triglyceral (TG) , cholesterol (Choi) , and true insulin (TI) were measured before and after sleep . The correlations between hypertension/serum leptin level and OS-AHS were analyzed. Results The blood pressure (in the morning) , especially DBP was significantly higher in OSAHS group than in non-OSAHS control group [(89.75 ± 2.04) mmHg υs. (81.63 ± 1.91) mmHg, P < 0.01]. DBP in OSAHS group was positively correlated with serum leptin and apnea hypopnea index ( AHI) (r = 0. 282, P < 0. 05; r = 0. 318, P < 0. 01). Logistic regression analysis showed that BMI ( P = 0. 029 ) , heart rate in the morning (P = 0. 030 ) , and leptin ( P = 0. 049 ) were independently correlated with the develop-ment of hypertension. ConclusionsOSAHS may independantly affect blood pressure, especially DBP, after waking up. BMI, HR in the morning, and serum leptin may be the independent correlates of hypertension.
