中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
36期
1-3
,共3页
谢伟基%张夏兰%张丽玲%洪楷%肖再雄%陈东晓%耿义群
謝偉基%張夏蘭%張麗玲%洪楷%肖再雄%陳東曉%耿義群
사위기%장하란%장려령%홍해%초재웅%진동효%경의군
狼疮肾炎%血液%尿△%中性粒细胞明胶酶相关脂质运载蛋白
狼瘡腎炎%血液%尿△%中性粒細胞明膠酶相關脂質運載蛋白
랑창신염%혈액%뇨△%중성립세포명효매상관지질운재단백
Lupus nephritis%Blood%Urine△%Neutrophil gelatinase-associated lipocalin
目的 测定狼疮性肾炎(LN)患者和健康成年人的血、尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)并分析其临床意义.方法 选取符合1997年美国风湿病学会修订的系统性红斑狼疮的诊断标准,同时合并有不同程度肾损害而确诊合并LN患者35例作为研究组,选取年龄、性别相匹配的健康成年人30例作为对照组,采用酶联免疫吸附技术(ELISA)分别测定血、尿NGAL的水平.另依据SLEDAI-2K的肾病活动指数将研究组患者分为肾病活动组(25例)与非肾病活动组(10例),并比较血、尿NGAL水平.结果 研究组患者尿NGAL水平为(78.94±81.97)μg/L,明显高于对照组的(28.50±18.08)μg/L,差异有统计学意义(P=0.002).肾病活动组尿NGAL水平为(92.90±94.88)μg/L,明显高于非肾病活动组的(48.20±24.77)μg/L,差异有统计学意义(P=0.049),两组血NGAL水平比较差异无统计学意义(P＞0.05).结论 LN患者尿NGAL可作为肾病活动性的指标,其升高原因可能与肾小管病变有关.
目的 測定狼瘡性腎炎(LN)患者和健康成年人的血、尿中性粒細胞明膠酶相關脂質運載蛋白(NGAL)併分析其臨床意義.方法 選取符閤1997年美國風濕病學會脩訂的繫統性紅斑狼瘡的診斷標準,同時閤併有不同程度腎損害而確診閤併LN患者35例作為研究組,選取年齡、性彆相匹配的健康成年人30例作為對照組,採用酶聯免疫吸附技術(ELISA)分彆測定血、尿NGAL的水平.另依據SLEDAI-2K的腎病活動指數將研究組患者分為腎病活動組(25例)與非腎病活動組(10例),併比較血、尿NGAL水平.結果 研究組患者尿NGAL水平為(78.94±81.97)μg/L,明顯高于對照組的(28.50±18.08)μg/L,差異有統計學意義(P=0.002).腎病活動組尿NGAL水平為(92.90±94.88)μg/L,明顯高于非腎病活動組的(48.20±24.77)μg/L,差異有統計學意義(P=0.049),兩組血NGAL水平比較差異無統計學意義(P＞0.05).結論 LN患者尿NGAL可作為腎病活動性的指標,其升高原因可能與腎小管病變有關.
목적 측정랑창성신염(LN)환자화건강성년인적혈、뇨중성립세포명효매상관지질운재단백(NGAL)병분석기림상의의.방법 선취부합1997년미국풍습병학회수정적계통성홍반랑창적진단표준,동시합병유불동정도신손해이학진합병LN환자35례작위연구조,선취년령、성별상필배적건강성년인30례작위대조조,채용매련면역흡부기술(ELISA)분별측정혈、뇨NGAL적수평.령의거SLEDAI-2K적신병활동지수장연구조환자분위신병활동조(25례)여비신병활동조(10례),병비교혈、뇨NGAL수평.결과 연구조환자뇨NGAL수평위(78.94±81.97)μg/L,명현고우대조조적(28.50±18.08)μg/L,차이유통계학의의(P=0.002).신병활동조뇨NGAL수평위(92.90±94.88)μg/L,명현고우비신병활동조적(48.20±24.77)μg/L,차이유통계학의의(P=0.049),량조혈NGAL수평비교차이무통계학의의(P＞0.05).결론 LN환자뇨NGAL가작위신병활동성적지표,기승고원인가능여신소관병변유관.
Objective To study the clinical significance ofneutrophil gelatinase-associated lipocalin (NGAL), which in serial plasma and urine samples was measured in participants with lupus nephritis (LN)and healthy persons. Methods NGAL in serial plasma and urine samples was measured by enzyme-linked immunosorbent assay (EL.ISA) in 35 patients with LN by 1997 ACR systemic lupus erythematosus (SLE)standard with varied degree of kidney damage and 30 healthy persons with matching sex and age in physical examination center. Disease activity was measured by the SLE disease activity index (SLEDAI-2K),and 35LN patients were classified in active group and (25 cases) non-active group (10 cases) according to the SLEDAI-2K. Results Urinary NGAL were significantly increased in LN patients [(78.94 ± 81.97) μg/L]compared with healthy persons[(28.50 ± 18.08) μ g/L] (P = 0.002). And urinary NGAL were significantly increased in active group [(92.90 ± 94.88) μg/L] compared with non-active group [(48.20 ± 24.77)μ g/L] (P = 0.049). NGAL in serial plasma had no statistically significant difference between active group and non-active group (P ＞0.05). Conclusions NGAL in urine but not in plasma represents a novel biomarker for renal disease activity in LN. The increase might be related to renal tubule pathological changes.
