中华超声影像学杂志
中華超聲影像學雜誌
중화초성영상학잡지
CHINESE JOURNAL OF ULTRASONOGRAPHY
2008年
4期
354-357
,共4页
张婷%李发琪%陈首名%付丽媛%龚晓波%王琦%彭娟%李崇燕%鲁力%王智彪
張婷%李髮琪%陳首名%付麗媛%龔曉波%王琦%彭娟%李崇燕%魯力%王智彪
장정%리발기%진수명%부려원%공효파%왕기%팽연%리숭연%로력%왕지표
高强度聚焦超声%造影剂%肝/损伤
高彊度聚焦超聲%造影劑%肝/損傷
고강도취초초성%조영제%간/손상
High intensity focused ultrasound%Contrast media%Liver/injuries
目的 探讨超声造影剂SonoVue用于增强高强度聚焦超声(HIFU)损伤山羊肝组织的可行性.方法 南江黄羊15只,采用自身对照,分为HIFU治疗组(对照组)和HIFU联合造影剂治疗组(实验组).治疗深度30 mm,分别在声功率为150 W、250 W、350 W条件下对肝定点辐照15 S.辐照后24 h处死动物,解剖观察凝固性坏死情况,并作病理切片分析.结果 在相同声辐照参数下,实验组凝固性坏死发生率及凝固性坏死区域长、宽、厚、体积均明显大于对照组(P＜0.05),随功率增加实验组凝固性坏死体积增加幅度较对照组更明显,实验组能效因子(EEF)明显小于对照组.凝固性坏死区与正常肝组织分界清楚,且病理切片显示损伤为不可逆性,分界处可见大量空泡.结论 HIFU联合微泡造影剂能在山羊肝中形成完全的凝固性坏死,同时提高凝固性坏死的损伤率,增大凝固性坏死体积,提高HIFU治疗效率.
目的 探討超聲造影劑SonoVue用于增彊高彊度聚焦超聲(HIFU)損傷山羊肝組織的可行性.方法 南江黃羊15隻,採用自身對照,分為HIFU治療組(對照組)和HIFU聯閤造影劑治療組(實驗組).治療深度30 mm,分彆在聲功率為150 W、250 W、350 W條件下對肝定點輻照15 S.輻照後24 h處死動物,解剖觀察凝固性壞死情況,併作病理切片分析.結果 在相同聲輻照參數下,實驗組凝固性壞死髮生率及凝固性壞死區域長、寬、厚、體積均明顯大于對照組(P＜0.05),隨功率增加實驗組凝固性壞死體積增加幅度較對照組更明顯,實驗組能效因子(EEF)明顯小于對照組.凝固性壞死區與正常肝組織分界清楚,且病理切片顯示損傷為不可逆性,分界處可見大量空泡.結論 HIFU聯閤微泡造影劑能在山羊肝中形成完全的凝固性壞死,同時提高凝固性壞死的損傷率,增大凝固性壞死體積,提高HIFU治療效率.
목적 탐토초성조영제SonoVue용우증강고강도취초초성(HIFU)손상산양간조직적가행성.방법 남강황양15지,채용자신대조,분위HIFU치료조(대조조)화HIFU연합조영제치료조(실험조).치료심도30 mm,분별재성공솔위150 W、250 W、350 W조건하대간정점복조15 S.복조후24 h처사동물,해부관찰응고성배사정황,병작병리절편분석.결과 재상동성복조삼수하,실험조응고성배사발생솔급응고성배사구역장、관、후、체적균명현대우대조조(P＜0.05),수공솔증가실험조응고성배사체적증가폭도교대조조경명현,실험조능효인자(EEF)명현소우대조조.응고성배사구여정상간조직분계청초,차병리절편현시손상위불가역성,분계처가견대량공포.결론 HIFU연합미포조영제능재산양간중형성완전적응고성배사,동시제고응고성배사적손상솔,증대응고성배사체적,제고HIFU치료효솔.
Objective To investigate the feasibility of enhancing therapeutic effects on goats' liver in vivo treated by high intensity focused ultrasound(HIFU)combined with microbubble contrast agent SonoVue.Methods Fifteen Nanjiang goats were adopted,own control was adopted in this study.One group received purely HIFU therapy(control group),another one was radiated with HIFU combined with SonoVue contrast agent(SonoVue group).The HIFU irradiating mode was dotted with 30 mm focal length and 150 W,250 W,350 W acoustic power respectively,and the exposure time was 15 s.Animals were sacrificed and dissected 24h later,and the sizes of necrotic region were measured.Specimens were collected for histological inspection.Results Under the same parameter of exposure,the maximum length,width,depth,and the mean volume of the tissue coagulated by HIFU in the SonoVue group were all significantly greater than those in control group(P＜0.05),the change of volume coagulated tissue was much more significant with the increase of the acoustic power.The energy effciency factor (EEF)of SonoVue group was significantly smaller than that of control group(P＜0.05).The demarcation line between the necrosis and normal region was clear and the necrosis was complete,no living cell.The boundary exist amount of bubbles.Conclusions The therapy of HIFU combined with microbubble eontrast agent can substantially enhance the biological effects of the treatment and improve the efficiency of HIFU therapy on goats liver.
