CAJ | 학술논문

目的探讨轻度认知功能障碍(MCI)患者神经心理学的特点. 方法对42例MCI患者和55例健康对照者进行多项神经心理学检查,包括简易精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)、临床痴呆评定量表(CDR)、语言流畅性测验(RVR)、韦氏智力测验(WAIS-RC)[包括数字广度测验(DS)、积木测验(BD)、相似性测验]、韦氏记忆测验(WMS-R)(包括逻辑记忆、联想学习、视觉再认、图片回忆)、日常生活能力量表(ADL),比较2组患者上述量表评分和MMSE、MoCA量表各亚项评分的差异.结果与对照者比较,MCI患者MMSE、MoCA总分和RVR、WAIS-RC、WMS-R分测验,MoCA量表各亚项(地点定向力除外),MMSE量表中计算与注意、延迟回忆两亚项评分较低,差异均有统计学意义(P<0.05).结论 MCI患者不仅记忆受损,其计算与注意力、命名、视空间结构能力、执行功能也可受损,尤以延迟回忆、计算与注意力受损明显.MoCA涵盖了重要的认知领域,能较全面评估MCI患者的认知功能,值的临床推广应用.
목적 탐토경도인지공능장애(MCI)환자신경심이학적특점. 방법 대42례MCI환자화55례건강대조자진행다항신경심이학검사,포괄간역정신상태검사량표(MMSE)、몽특리이인지평고량표(MoCA)、림상치태평정량표(CDR)、어언류창성측험(RVR)、위씨지력측험(WAIS-RC)[포괄수자엄도측험(DS)、적목측험(BD)、상사성측험]、위씨기억측험(WMS-R)(포괄라집기억、련상학습、시각재인、도편회억)、일상생활능역량표(ADL),비교2조환자상술량표평분화MMSE、MoCA량표각아항평분적차이.결과 여대조자비교,MCI환자MMSE、MoCA총분화RVR、WAIS-RC、WMS-R분측험,MoCA량표각아항(지점정향력제외),MMSE량표중계산여주의、연지회억량아항평분교저,차이균유통계학의의(P<0.05).결론 MCI환자불부기억수손,기계산여주의력、명명、시공간결구능력、집행공능야가수손,우이연지회억、계산여주의력수손명현.MoCA함개료중요적인지영역,능교전면평고MCI환자적인지공능,치적림상추엄응용.
Objective To explore the neuropsychological features of patients with mild cognitive impairment (MCI). Methods Forty-two patients with MCI and 50 normal controls were examined with a series of neuropsychoiogieai tests. These test included mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), clinical dementia rating scale (CDR), rapid verbal retrieve (RVR), activity of daily living scale (ADL), Wechsler intelligence scale (WAIS-RC) and its sub-tests (digit span[DS], blocks design test [BD], similarity test), Wechsler memory scale (WMS-R) and its sub-tests (logical memory, associative learning, visual recognition, picture recall). The difference of these data were compared and analyzed. Results The patients with MCI had significantly lower MMSE total score, MoCA total score, RVR score, WAIS-RC score and its sub-tests scores, WMS-R score and its sub-test scores than healthy controls (P<0.05), but no significant differences were found between the 2 groups in ADL score (P>0.05). For the MoCA sub-items, the patients with MCI had significantly lower scores than healthy controls in all the cognitive function measures except fixed orientation (P<0.05). Conclusions In addition to memory impairment, naming, visuospatial ability and executive function may also be impaired in patients with MCI; delayed recall, calculation and attention are obviously impaired in patients with MCI. MoCA, covering the important cognitive domains, can comprehensively assess the cognitive functions of patients with MCI and has its value in the clinical application.