天然产物研究与开发
天然產物研究與開髮
천연산물연구여개발
NATURAL PRODUCT RESEARCH AND DEVELOPMENT
2007年
3期
374-378
,共5页
木棉叶%木棉素%知母宁%单晶结构%活性位点
木棉葉%木棉素%知母寧%單晶結構%活性位點
목면협%목면소%지모저%단정결구%활성위점
Gossmpinus malabarica(DC.)%gossampinus xanthome%chinonin%single-crystal structure%active site
从木棉科植物木棉(Gossmpinus malabarica (DC.) Mer)的叶中首次分离纯化得到木棉素(Gossampinus xanthone).经元素分析、波谱数据和X-射线单晶衍射分析,确认该化合物为1,3,6,7-四羟基-2-β-D-吡喃葡萄糖基口山酮(1,3,6,7-terahydroxy-2-β-D-glucopyanosyl-xanthone).C19H18O11,M=422.34.晶体属斜方晶系,空间群P21212.晶胞参数a=7.265(5),b=30.086(4),c=8.342(2)(A),V=1822(2)(A)3 ,Z=4,Dc=1.54 g/cm3,F(000)=880.木棉素分子由平面口山酮基和椅式葡萄糖基通过C(2)-C(1')键连接而成.两基团的两个最小二乘平面间的夹角约为76.5°.存在分子内氢键O┄H…O的同时,也有分子间O┄H…O氢键.
從木棉科植物木棉(Gossmpinus malabarica (DC.) Mer)的葉中首次分離純化得到木棉素(Gossampinus xanthone).經元素分析、波譜數據和X-射線單晶衍射分析,確認該化閤物為1,3,6,7-四羥基-2-β-D-吡喃葡萄糖基口山酮(1,3,6,7-terahydroxy-2-β-D-glucopyanosyl-xanthone).C19H18O11,M=422.34.晶體屬斜方晶繫,空間群P21212.晶胞參數a=7.265(5),b=30.086(4),c=8.342(2)(A),V=1822(2)(A)3 ,Z=4,Dc=1.54 g/cm3,F(000)=880.木棉素分子由平麵口山酮基和椅式葡萄糖基通過C(2)-C(1')鍵連接而成.兩基糰的兩箇最小二乘平麵間的夾角約為76.5°.存在分子內氫鍵O┄H…O的同時,也有分子間O┄H…O氫鍵.
종목면과식물목면(Gossmpinus malabarica (DC.) Mer)적협중수차분리순화득도목면소(Gossampinus xanthone).경원소분석、파보수거화X-사선단정연사분석,학인해화합물위1,3,6,7-사간기-2-β-D-필남포도당기구산동(1,3,6,7-terahydroxy-2-β-D-glucopyanosyl-xanthone).C19H18O11,M=422.34.정체속사방정계,공간군P21212.정포삼수a=7.265(5),b=30.086(4),c=8.342(2)(A),V=1822(2)(A)3 ,Z=4,Dc=1.54 g/cm3,F(000)=880.목면소분자유평면구산동기화의식포도당기통과C(2)-C(1')건련접이성.량기단적량개최소이승평면간적협각약위76.5°.존재분자내경건O┄H…O적동시,야유분자간O┄H…O경건.
The purpose of the thesis is study single-crystal structures of gossampinus xanthome isolated firstly from Gossampinus malabarica leaf.The 1,3,6,7-terahydroxy-2-β-D-glucopyanosyl xanthone as conformational as chinonin and mangiferin was established on the basis of spectral and chemical evidences.Its crystal structure of it was firstly investigated by single-crystal X-ray crystallographic analysis crystallizes in the triclinic system,space group P21212 with a=7.265(5),b=30.086(4),c=8.342(2)(A),V=1822(2)(A)3 ,Z=4,Dc=1.54 g/cm3,F(000)=880.It is constituted by xanthone group and glucopyranosyl group.The xanthone group is rather flat in shapic,which suggested the presence of a large conjugation system,while the glucopyranosyl group adopts a chair conformation.The dihedral angle between both LS planes of the two groups is about 76.5°.The molecules of the title compound are linked by O┄H…O hydrogen bonds in the crystal.A recent study described as phenolic hydroxyls in xanthone are the main active groups for scavenging .OH,O2,NO.
