CAJ | 학술논문

目的探究特发性脱髓鞘性视神经炎(idiopathic demyelinating optic neuritis,IDON)和早期多发性硬化(multiple sclerosis,MS)患者认知功能损害的形式、特点.方法收集首都医科大学附属北京同仁医院神经内科2007年6月至2008年3月诊治IDON连续病例57例,根据头颅MRI表现分为视神经炎伴脑白质病灶组(IDON with abnormal MRI,IDON-A)和视神经炎不伴脑白质病灶组(IDON with normal MRI,IDON-N);另收集病程≤5年且扩展功能障碍状态量表(expanded disability status scale,EDSS)评分≤4.0分的MS病例20例组成早期MS组.所有入组患者和健康对照接受神经心理学测验系统评价注意力及信息处理速度、执行功能、记忆、定向、计算、语言、视空间功能等认知功能.结果神经心理学研究发现,IDON-A组及MS组的注意力、信息处理速度、言语和空间记忆力较IDON-N组及正常对照显著下降,差异有统计学意义(P=0.000,0.001,0.003,0.018,0.036);IDON-A组及MS组的执行功能较正常对照组损害明显(P=0.000,0.001,0.036,0.020),与IDON-N组比较差异无统计学意义.IDON-A组与早期MS组所有成绩差异均无统计学意义;IDON-N组大部分测验成绩与对照组比较差异无统计学意义.IDON和早期MS患者的认知损害与病程长短、神经功能缺损具有弱相关性.结论 IDON患者和早期MS患者已有明确认知损害,主要包括信息处理速度、注意力、执行功能、言语和空间记忆力等方面.
목적 탐구특발성탈수초성시신경염(idiopathic demyelinating optic neuritis,IDON)화조기다발성경화(multiple sclerosis,MS)환자인지공능손해적형식、특점.방법 수집수도의과대학부속북경동인의원신경내과2007년6월지2008년3월진치IDON련속병례57례,근거두로MRI표현분위시신경염반뇌백질병조조(IDON with abnormal MRI,IDON-A)화시신경염불반뇌백질병조조(IDON with normal MRI,IDON-N);령수집병정≤5년차확전공능장애상태량표(expanded disability status scale,EDSS)평분≤4.0분적MS병례20례조성조기MS조.소유입조환자화건강대조접수신경심이학측험계통평개주의력급신식처리속도、집행공능、기억、정향、계산、어언、시공간공능등인지공능.결과 신경심이학연구발현,IDON-A조급MS조적주의력、신식처리속도、언어화공간기억력교IDON-N조급정상대조현저하강,차이유통계학의의(P=0.000,0.001,0.003,0.018,0.036);IDON-A조급MS조적집행공능교정상대조조손해명현(P=0.000,0.001,0.036,0.020),여IDON-N조비교차이무통계학의의.IDON-A조여조기MS조소유성적차이균무통계학의의;IDON-N조대부분측험성적여대조조비교차이무통계학의의.IDON화조기MS환자적인지손해여병정장단、신경공능결손구유약상관성.결론 IDON환자화조기MS환자이유명학인지손해,주요포괄신식처리속도、주의력、집행공능、언어화공간기억력등방면.