CAJ | 학술논문

目的探讨血液灌注(HP)对维持性血液透析(MHD)患者微炎性反应状态的影响.方法 50例行MHD治疗的慢性肾衰竭患者(MHD组),按随机数字表法分为两组:HP联合血液透析(HD)组(HP+HD组,25例)和单纯HD组(HD组,25例),并设对照组(25例).检测治疗前及治疗24周后血清高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平.结果与对照组比较,MHD组血清hs-CRP[(6.72±263)mg/L 比(1.35±0.92)mg/L]、IL-6[(348.83±64.41)ng/L比(54.49±2247)ng/L]、TNF-α[(7.52±317)ng/L比(2 53±0.88)ng/L]水平明显增高(P＜0.05).治疗前HP+HD组与HD组血清hs-CRP、IL-6、TNF-α水平比较差异无统计学意义(P>0.05).治疗后,与HD组比较,HP+HD组血清hs-CRP[(4.78±2.49)mg/L比(6.89±2.69)mg/L]、lL-6[(260.54±56.72)ng/L比(357.14±56.37)ng/L]、TNF-α[(5.36±241) ng/L比(7.49±2.87)ng/L]水平明显下降(P＜0.05).结论 HP可改善MHD患者微炎性反应状态.
목적 탐토혈액관주(HP)대유지성혈액투석(MHD)환자미염성반응상태적영향.방법 50례행MHD치료적만성신쇠갈환자(MHD조),안수궤수자표법분위량조:HP연합혈액투석(HD)조(HP+HD조,25례)화단순HD조(HD조,25례),병설대조조(25례).검측치료전급치료24주후혈청고민C반응단백(hs-CRP)、백세포개소-6(IL-6)급종류배사인자-α(TNF-α)수평.결과 여대조조비교,MHD조혈청hs-CRP[(6.72±263)mg/L 비(1.35±0.92)mg/L]、IL-6[(348.83±64.41)ng/L비(54.49±2247)ng/L]、TNF-α[(7.52±317)ng/L비(2 53±0.88)ng/L]수평명현증고(P＜0.05).치료전HP+HD조여HD조혈청hs-CRP、IL-6、TNF-α수평비교차이무통계학의의(P>0.05).치료후,여HD조비교,HP+HD조혈청hs-CRP[(4.78±2.49)mg/L비(6.89±2.69)mg/L]、lL-6[(260.54±56.72)ng/L비(357.14±56.37)ng/L]、TNF-α[(5.36±241) ng/L비(7.49±2.87)ng/L]수평명현하강(P＜0.05).결론 HP가개선MHD환자미염성반응상태.
Objective To observe the effect of hemoperfusion on micro-inflammation in patients with maintenance hemodialysis (MHD).Methods Fifty MHD patients (MHD group) and 25 healthy volunteers (control group) were involved in this study.The MHD patients were divided into two groups by random digits table:hemoperfusion combined with hemodialysis group (HP + HD group,25 cases) and hemodialyais group (HD group,25 cases).The plasma levels of micro-inflammatory cytokines including high-sensitive C-reactive protein (hs-CRP),interleukin-6 (IL-6) and tumor necrosis faetor-α (TNF-α ) were measured before and after treatment.Results The plasma levels of hs-CRP,IL-6 and TNF-α in MHD group were significantly higher than those in control group [(6.72 ± 2.63) mg/L vs.(1.35 ± 0.92) mg/L,(348.83 ± 64.41) ng/L vs.(54.49 ±22.47) ng/L,(7.52 ± 3.17) ng/L vs.(2.53 ±0.88) ng/L](P＜0.05).There was no significant difference in the plasma levels of hs-CRP,IL-6,TNF-α before treatment between HD group and HP+HD group (P＞0.05),Compared with those in HD group,the plasma levels of hs-CRP,IL-6 and TNF-α after treatment in HP+HD group were significantly decreased [(4.78 ±2.49) mg/L vs.(6.89 ±2.69) mg/L,(260.54 ±56.72) ng/L vs.(357.14 ±56.37) ng/L,(5.36 ±2.41) ng/L vs.(7.49 ±2.87) ng/L] (P <0.05).Conclusion Hemoperfusion improves micro-inflammation in patients with MHD.